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Conference reports

HIV infection in the brain: a long-term limitation of HAART?

When to start HAART – a key research question with the least available data

Major studies rule out any benefit of Interleukin-2 (IL-2): results from ESPRIT and SILCAAT

Higher rates of non-AIDS cancers in HIV positive people

Effect of breast feeding vs formula feeding on maternal health

PEPI-Malawi

Premature delivery and mother-to-child HIV transmission: a risk/benefit analysis among women receiving HAART

Risk factors for adverse pregnancy outcomes in Botswana

Higher risk of transmission with delayed control of maternal viral load despite viral loads of <500 copies/mL at delivery

Lopinavir/r containing regimen superior to nevirapine containing regimen in women previously exposed to single dose nevirapine

Covering the nevirapine tail

Effect of single dose nevirapine on subsequent nevirapine-containing HAART: long term outcomes

High rates of HIV acquisition in pregnancy and post partum in Francistown, Botswana

Children on HAART do extremely well at South African clinic

New boosting alternatives to ritonavir: GS-99350 and SPI-452

Interactions with raltegravir: with twice-daily atazanavir and standard dose lamotrigine

Effect of tenofovir on abacavir phosphorylation

Nevirapine: fluconazole and TB treatment

PI interactions: lopinavir/rifampicin, saquinavir, atazanavir/tenofovir in pregnancy

Identification of drug interactions in clinical practice

Effect of substance abuse on ART pharmacokinetics

9th International Congress on Drug Therapy in HIV Infection, 9-13 November 2008, Glasgow

Summary of antiretroviral studies at Glasgow

The Antiretroviral Pregnancy Registry: individual drug safety reports on health of infants exposed to ARVs during pregnancy

Initial results from PENTA 11 trial of planned treatment interruption

Inflammation and coagulation markers askew in children with higher HIV RNA

Dosing of lopinavir/ritonavir in the CHIPS cohort

Number needed to treat to harm (NNTH) analysis of impact of underlying cardiovascular factors on risk of abacavir-related heart attack

Bone disease and HIV

Renal tubule damage with tenofovir despite normal glomerular function

10th International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV, 6-8 November 2008, London, UK

Report from the 10th IWADRLH by Jacqueline Capeau

Report from the 10th IWADRLH by Michael Dubé

Impact of body changes on the quality of life of HIV-positive treatment-experienced patients: an online community-based survey

48th Annual International Conference on Antimicrobial Agents and Chemotherapy (ICAAC), 25-28 October 2008, Washington DC

Antiretroviral Pregnancy Registry finds no increase in congenital anomalies with exposure to tenofovir

No association between maternal antiretrovirals in pregnancy and congenital anomalies

Pharmacokinetics of saquinavir/ritonavir in pregnancy

Course of labour in pregnant HIV-positive women with no contraindication for vaginal delivery

Four weeks of antiretroviral prophylaxis is sufficient for HIV-exposed infants

HAART suppresses genital tract HIV shedding in HIV/HSV co-infected women

Efavirenz significantly reduces levels of some oral contraceptives

Lack of efficacy of isoniazid (INH) prophylaxis and PK evaluation in South African infants

48-week data for darunavir/ritonavir (DRV/r) in treatment-experienced children and adolescents

Greater lipodystrophy risk in older US children with low viral load

Studies of pipeline drugs: RDEA806, PRO140, bevirimat, elvucitabine

Maraviroc trial results reanalysed using more sensitive CCR5 tropism test

Other antiretroviral studies at ICAAC

High rate of rash in HIV negative volunteers combining raltegravir and darunavir

Bone loss in SMART study

Parathyroid hormone and vitamin D levels in patients using tenofovir

Haemoglobin A1c (HbA1c) may underestimate glycaemia in patients with diabetes on HIV therapy

Statin use in HIV-positive patients

HIV reinfection reported in 10% of couples in Zambian study

Drug interaction studies with approved drugs

Non alcoholic fatty liver disease (NAFLD) is common among HIV-positive patients

17th International AIDS Conference, 3-8 August 2008, Mexico City

Abacavir and heart disease: SMART study supports an abacavir-associated increased risk of cardiovascular disease

HAART use in pregnancy and preterm delivery and low birth weight

Reasons for mother to child transmission in England

New paediatric formulations of ARVs

3rd International Transmission Workshop, 1-2 August 2008, Mexico City

Intermittent tenofovir/FTC PrEP offers monkeys some protection

Tenofovir/FTC gel protects female monkeys from SHIV

Recently infected HIV-positive Quebec residents cause more than half of new cases

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