Conference reports

Very low rate of MTCT in women on HAART in UK and Ireland who achieve viral suppression

Predictors of mother to child transmission among women initiating HAART in pregnancy in a South African cohort

Maternal and infant outcomes from the DREAM programme

Nevirapine-resistant HIV present in the latent reservoir following single-dose nevirapine for MTCT prevention

Tenofovir plus FTC reduce NNRTI resistance following single dose nevirapine

Response to treatment after single dose NVP exposure in women

Response to treatment after single dose NVP exposure in infants

Other studies looking at birth outcomes

Infant prophylaxis for postnatal transmission

Antiretroviral drug concentrations in breast milk and breastfeeding infants

Maternal breastfeeding prophylaxis

Risk factors for breastfeeding transmission

UK cohort reports sexual HCV reinfection in at least 5% HIV-positive gay men following sustained response to treatment

MELD score predictive of pre-transplant mortality in HCV coinfected patients

Does abacavir decrease SVR rates with HCV treatment?

No effect of interferon maintenance therapy on fibrosis progression in non-responders

Stem cell transplant from HLA-matched CCR5-delta 32 deleted donor suppresses viraemia in recipient for 8 months without HAART

Risk factors for AIDS-defining and non AIDS-defining cancers

CROI 2008 – 12 key areas of research: non-technical summary of 25 studies and presentations

15th Conference on Retroviruses and Opportunistic Infections, 2-6 February 2008, Boston

Increased risk of myocardial infarction associated with abacavir and ddI

Position statement by the D:A:D steering committee

3rd International Workshop on Targeting HIV Entry, 7-9 December 2007, Washington DC

CXCR4-using HIV found in 8.5% during early HIV infection

Background drugs and low maraviroc levels explain resistance in Motivate studies

38th World Conference on Lung Health of the Union Against TB and Lung Disease, December 2007, Cape Town

Treatment outcomes in patients who received rifampicin with nevirapine or efavirenz

11th European AIDS conference (EACS), October 24-27 2007, Madrid

New European guidelines launched (2007)

Saquinavir/r non-inferior to Kaletra at week 48 (Gemini study)

Darunavir once-daily is non-inferior to lopinavir/r in treatment-naive patients at 48 weeks (Artemis study)

Tesamorelin (TH9507) reduces abdominal fat in patients with HIV-related lipodystrophy: 52 week results

Drug interaction studies presented at EACS

BHIVA Autumn conference, 11-12 October 2007, London

Audit of treating naive patients showed basic UK guidelines not followed in over 25% patients; 60% patients start with a CD4 count <200 cells/mm3

4th IAS Conference on HIV Pathogenesis, Treatment and Prevention, 22-25 July 2007, Sydney

HIV viraemia may explain increased risk of cardiovascular disease, death and other serious events in people interrupting treatment in the SMART trial: new study to randomise people with CD4 counts >500 to start immediate treatment or defer to <350 cells/mm3

CD4 increases in immunological non-responders despite suppressive therapy following switch to nuke-sparing regimen of ATZ/SQV/r

Darunavir/r shows superiority over lopinavir/r at 48 weeks in TITAN trial

Maraviroc fails to show non-inferiority to efavirenz in treatment-naive patients: 48 week results

Importance of using maraviroc in combination with other active drugs in treatment-experienced patients

Week 48 raltegravir results in treatment-naive phase II dose-finding study

DUET studies clarify antiviral efficacy of etravirine and cross-resistance profile to other NNRTIs

Boosting atazanavir in treatment-naive patients, and impact on lipids after switching from lopinavir/r

Saquinavir/r vs lopinavir/r in treatment-naive patients

Fosamprenavir/r vs atazanvir/r in treatment-naive patients

Antiretroviral therapy initiated before 12 weeks of age reduces early mortality in young infants; interim results from the CHER study

Very low transmission rates among breastfeeding women receiving ART

Use of pre-exposure prophylaxis (PrEP) by sero-different couples wanting to conceive a child

Increased incidence of miscarriage with efavirenz use

No impact of HSV-2 suppressive therapy on HIV incidence

Penile washing directly after sex increased the risk of acquiring HIV: circumcision effective for men in high prevalence populations no protective effect in gay men

HBV or HCV coinfection produced higher risk from treatment interruptions: drug holidays and hepatitis don’t mix

9th International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV, 19-21 July 2007, Sydney

Can nevirapine be safely substituted for other agents in those with high CD4 cell counts and virologic suppression?

Do children with perinatally acquired HIV infection have problems with metabolism and body shape?

The growth hormone releasing factor analogue tesamorelin (TH9507) reduces visceral fat, but what else does it do?

Does diabetes have the same impact on cardiovascular risk in HIV-positive patients as it does in the general population?

Can nucleoside RT inhibitors directly cause insulin resistance?

Do dyslipidemia, insulin resistance, and body shape changes differ according to race or ethnicity?

Is lipoatrophy associated with vascular dysfunction?

XVI International HIV Drug Resistance Workshop, 12-16 June 2007, Barbados

Integrase inhibitors and resistance

Treatment failure and tropism changes in maraviroc trial related to previously undetected CXCR4, rather than a mutational shift from CCR5

Mechanisms of failure to CCR5 inhibitors is not explained by mutation in the V3 loop, cross-resistance between CCR5 inhibitors is likely

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