Antiretrovirals

Cobicistat has little impact on CYP2D6 and CYP2B6

Atazanavir levels indicate need for higher dose during pregnancy

Etravirine lowers levels of maraviroc given at 300 or 600 mg twice daily

Once-daily 150-mg maraviroc explored in people taking atazanavir/ritonavir

Lopinavir troughs lower in children on once-daily dose with efavirenz

Dose optimisation: 50 mg ritonavir-boosting, 3TC dosing and raltegravir once-daily

Rapid report: state of HCV policy, treatment, access

When to start ART in patients co-infected with TB: results from two trials presented at CROI

Inflammation and intervention: how does HIV cause AIDS and how does it cause disease despite ART

New antiretrovirals: dolutegravir, entry inhibitor (BMS-663068) and tenofovir pro-drug (GS-7340)

Immune-based treatment increases HIV-resistant CD4 cells in phase 1 study

Antiretroviral prevention: oral PrEP, gels and treatment studies

Further efficacy analyses from the iPrEx study

Topical gels as PEP and PrEP: animal and human studies

Maternal risk following short course HAART

Pre-term delivery and HAART

HAART more effective than AZT monotherapy in the Botswana PMTCT programme

Lopinavir/r monotherapy for PMTCT

First results from telaprevir in HIV/HCV coinfection

London HIV Consortium issues new guidelines for ARV prescribing (2011)

EMA issue restricted indication for d4T (stavudine)

Changes to starting dose of saquinavir in naive patients

FDA approve nevirapine XR

Lopinavir/r oral solution

Atazanavir use during pregnancy

Nelfinavir interaction with warfarin

Lopinavir/ritonavir: women versus men

Quality of life in the GRACE study

Antiretroviral pharmacokinetics in women with undetectable viral load

No association between bone mineral density and lipodystrophy in women receiving antiretroviral therapy

The impact of antiretroviral treatment on fertility intentions in South Africa

US adult treatment guidelines updated – January 2011

FDA safety updates to antiretroviral labels

Darunavir once-daily indication in treatment experienced adults

Virological findings from the SARA trial ofboosted protease inhibitor monotherapy

Nevirapine exposure was not associated with hypersensitivity in patients from Malawi

Estimating the number of people in a country or region with HIV who are undiagnosed and in need of ART

Efavirenz versus nevirapine based first linetreatment in a South African cohort

GSK572: 24-week results in treatment-naive and raltegravir-experienced patients

Consensus guidelines recommend routine use of genotypic tropism testing: new focus on maraviroc as a switching option (2010)

Muscle weakness or pain analysed as possible raltegravir side effect

Adding maraviroc does not boost CD4s inrandomised trial

Switch to twice-daily unboosted atazanavir outdoes switch to once-daily dose

Small but higher rates of AIDS and non-AIDS complications with uncontrolled HIV despite CD4s over 350

Once-daily raltegravir fails to demonstrate non-inferiority compared to twice-dailydosing in phase 3 treatment naive study

FDA safety updates to antiretroviral labels

Update to US saquinavir label

Raltegravir pharmacokinetics inpregnancy

Low birth weight associated with HAART in pregnancy in Zambia

Bilirubin levels in infants following in utero atazanavir exposure compared to exposure to other antiretrovirals

Novel mutations and shifting susceptibility to darunavir and tipranavir

Four-drug single-pill antiretroviral equivalent to Atripla at 48 weeks

High rates of bone loss and progression with HIV in longitudinal study

Spray-dried nanoparticle formulation of efavirenz

Switching boosted-PIs to raltegravir

Early infant diagnosis

Efavirenz-based regimens among womenof reproductive age receiving ART in Johannesburg

START study given green light for full study

Saquinavir prolongation of QT interval: Rocheissue Dear Doctor letter

Development of chronic kidney disease and antiretroviral use in EuroSIDA cohortsince 2004

Rilpivirine (TMC-278) vs efavirenz in treatment-naive patients: phase 3 results

Once-daily nevirapine extended release (XR) is non-inferior to current formulation

GSK572 (dolutegravir): second-generation integrase inhibitor

TBR-652: early results for CCR5 inhibitor

Atazanavir/r plus maraviroc or tenofovir/FTC in treatment-naive patients

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