HTB

Conference reports

Change from CCR5 to CXCR4 phenotype may affect immunologic responses

ddI EC (Videx) study confirms and clarifies dosing on an empty stomach

Swatch study: should we be cycling drugs?

New HIV drugs, resistance, pharmacogenomics

Antiretroviral therapy

Immunopathogenesis of HIV infection

3rd International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV, Athens, 23-26 October 2001

Insulin resistance

Thyroid function abnormalities

Lipodystrophy and metabolic changes in children

Bone studies at lipodystrophy workshop

8th European Conference on Clinical Aspects and Treatment of HIV-infection, Athens, 28-31 October 2001

HIV drug resistance can develop under HAART at low levels of viraemia

Combinations of lopinavir/r and amprenavir in heavily treatment experienced patients

Further reports of benefits of polylactic acid for facial lipoatrophy

GigaHAART study shows benefit of treatment interruption prior to treatment with >7 drugs in highly treatment experienced patients

Tenofovir DF 907 study

The Max Cmin 1 trial: indinavir/ritonavir vs. saquinavir/ritonavir

No significant drug interactions found between tenofovir DF and indinavir, lopinavir/r, lamivudine, or efavirenz

Ritonavir corrects drug interaction between efavirenz and saquinavir

Lopinavir/r effective in naive patients after three years of treatment

1st IAS Conference on HIV Pathogenesis and Treatment, July 8-11 2001, Buenos Aires, Argentina

Lipodystrophy and metabolic complications

Lipodystrophy and metabolic disturbances

Pharmacology at 1st IAS

Drug-drug interactions

Entry inhibitor updates from the 1st IAS

Structured treatment interruptions (STIs) and structured intermittent therapy (SITs)

Adverse events with antiretrovirals

5th International Workshop on HIV Drug Resistance, 4-8 June 2001, Scottsdale, Arizona

Anti-HIV immune responses and partial viral suppression

HIV resistance, phenotypic drug susceptibility and viral fitness

SWATCH – alternating antiretroviral regimens

Structured treatments interruptions

Importance of additional active drugs for NNRTI-naive patients using NNRTI-based salvage regimens

NNRTI and PI drug plasma levels are as critical as drug sensitivity in achieving treatment success in antiretroviral experienced patients

Increased prevalence of transmission of drug resistant HIV and reduced response in newly infected subjects in nine US cities

Role of codon-69 variants in reduced susceptibility to nucleoside analogues

Selection of zidovudine resistance in a distinct class of wild-type HIV-1 from drug naive people

Nucleoside resistance pathways may differ between HIV-1 and HIV-2

Role of Y318F mutation in NNRTI resistance

4th International Conference on Nutrition and HIV Infection and the 2nd European Workshop on Lipodystrophy, April 19-21, 2001, Cannes, France

4th International Conference on Nutrition and HIV Infection and the 2nd European Workshop on Lipodystrophy – pt 2

Keystone Symposium on HIV, March 28-April 3, Keystone, Colorado: more than one way to skin a virus: innate immune factors that suppress HIV replication

2nd International workshop on Clinical Pharmacology of HIV Therapy, 2-4 April, Noordwijk, The Netherlands

First randomised trial shows clinical benefit of TDM for people using nelfinavir or indinavir containing combinations

Clinical Pharmacology of Antiretroviral Therapy, Liverpool, UK , March 2001

8th Conference on Retroviruses and Opportunistic Infections

Paediatric treatment issues at the 8th CROI

8th Conference on Retroviruses and Opportunistic Infections, February 4-8 2001, Chicago, USA

From talk to action in fighting AIDS in the developing countries: 8th Retrovirus Conference opening session

Differentiating within and between drug classes: sometimes it’s toxicity, sometimes its efficacy

Intermittent versus continuous HAART

Viral load “blips” and eventual rebound

Interaction between garlic and saquinavir and underreporting of alternative treatment use

Solid organ transplant in HIV/hepatitis co-infected patients

HIV and women – overview

Update on HIV drug resistance

Update and review of bone studies

Treatment interruptions, structured and unplanned, immunotherapy and what’s in store

Primary infection and treatment issues

Fifth International Congress on Drug Therapy in HIV Infection, 22-26 October 2000, Glasgow, UK

Treatment strategies in 2000: planning first-line (and therefore, second-line) therapy

When should HAART be started?

MDR resistance transmission increases in the UK

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