HTB

Paediatric care

Nevirapine pharmacokinetics with infant prophylaxis

Paediatric studies at EACS: trends in antiretroviral use in the Madrid Cohort; life expectancy significantly increased HIV/HCV co-infected children since HAART; use of tenofovir in treatment experienced children; switching to lopinavir/r from double protease inhibitor regimen; once daily lopinavir/r, 3TC and abacavir; planned treatment interruptions in children

Comparison of pharmacokinetics of originator and generic liquid formulations and split tablets in Malawian children

US paediatric guidelines updated (Feb 2006)

Pharmacokinetics of nevirapine in HIV positive children receiving Thai fixed dose combination

Lopinavir/r use in children less than two years old – promising results despite low plasma levels

Favourable outcomes in children treated with HAART in the MSF programmes

Encouraging results with cut up generic fixed dose combination tablets in Uganda

Predictors of survival at three years follow up for HIV-infected children in Cote D’Ivoire

Underdosing of ARVs in children: results from CHIPS cohort

Dosing nevirapine in children

Intracellular NRTI-triphosphate levels in children are similar to adults

Once-daily lopinavir/ritonavir for children may offer advantages

Lopinavir/ritonavir for young infants

Paediatric dose finding atazanavir and atazanavir/ritonavir

Switching d4T to tenofovir and protease inhibitor to efavirenz

US guidelines on paediatric care updated (March 2005)

Paediatric care in lower income settings

Tenofovir not linked to bone toxicity in children followed for one year

Higher nevirapine doses for children leads to better outcome

Long-term response to FTC in children is similar to adults

CHIPS data finds response to HAART varies with age in children

HAART is effective in African children in a resource-limited setting

Predictive factors of virologic success in HIV positive children treated with lopinavir/ritonavir

Inventive ways to explain HAART and adherence to children

Isoniazid has early and unexpected benefit in reducing childhood mortality

Pharmacokinetic characteristics of ritonavir, zidovudine, lamivudine, and stavudine in children with HIV

More positive children are surviving into adult life and require tailored services

Higher nelfinavir concentrations improve response in children

PK of once daily lopinavir/r in children

Children’s HIV National Network (CHINN) Review

FDA approves new paediatric dose of nelfinavir

Tenofovir studies in children

Should treatment be started in all newborns infected with HIV?

Tenofovir levels in children approach adult values

Study suggests paediatric dose of emtricitabine (FTC)

HIV production in children with “undetectable” viral load

Host genetic factors are important in disease progression in children

Dramatic decline in mortality, disease progression and hospital admissions in children with HIV infection in the UK and Ireland

New tool for assessing risks of disease progression and death based on age, CD4 percentage and viral load in HIV-infected children

Rituximab as single agent reversed paediatric Non-Hodgkins Lymphoma (NHL)

Perinatal antiretroviral treatment and haematopoiesis in HIV-uninfected infants

Higher than currently recommended NVP dose shows greater efficacy in HIV-infected children

Nevirapine and MTCT: the single-dose backlash

Risk factors for paediatric HIV malignancies

TREC analysis shows little thymic damage in HIV-positive adolescents

Metabolic abnormalities in protease inhibitor-treated and protease naïve children

Paediatrics: neurological and developmental outcomes

Pediatric studies from 10th CROI

Adverse drug reactions and lipodystrophy in children

Antiretrovirals have neurologic benefits in children

Early data highlight ribavirin’s anti-adenovirus potential

Four drug regimen for infants

Emergence of resistance in children treated with ddI/d4T after treatment to reduce MTCT

Increased risk of heart abnormalities in children born to mothers with HIV-1

Increased incidence of osteonecrosis of the hip observed in HIV-infected children

CCR5 density on CD4 cells governs course of HIV infection in children

Saquinavir is a suboptimal treatment for children unless used in combination

Mothers, orphans, and prevention of paediatric AIDS

Birth defects linked to use of certain drugs during pregnancy

Immune reconstitution in children treated with HAART is independent of age and pre-treatment immune status

Lipodystrophy and metabolic changes in children

Syncytium inducing viral phenotype halves thymic T cell production in children

Children with advanced disease who take HAART experience immune reconstitution

EC approves abacavir for use by HIV-infected children

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