HTB

2003

Bush blocks deal allowing cheap drugs

Roche to sell nelfinavir, saquinavir at cost to least-developed nations

South Africa appoints another dissident

US implementation of large-scale smallpox vaccination plan has special implications for people with HIV

UK HIV new cases at record high

Trizivir-only arm closed in PI-sparing, naïve therapy trial

Reduced testosterone levels in HIV-positive women

Fosamprenavir expanded access in UK

European approval of adefovir for hepatitis B

European activists highlight importance of gender based research: women experience HIV differently

Roche prices enfuvirtide (T-20) at €18,980 a year – making it the most expensive HIV drug yet

European positive opinion for tenofovir for first-line therapy

Vaxgen announces disappointing results from first large international vaccine trial

GMHC criticises Vaxgen for obfuscation of trial results of its AIDS vaccine

Antibiotic-resistant skin infections spreading among gay men, also in prisons

Further Glasgow and Retrovirus reports

Medscape: articles in full from AIDS, Journal AIDS etc

Contents of newsletters now online: Beta, amfAR Insider, PRN Notebook, GMHC Treatment Issues

New HIVinSite Knowledge Base chapters; new website for information on herbs and supplements

HHS Clinical Guide on Palliative Care of HIV/AIDS Patients

Volume 4 Number 3 April 2003 PDF

Volume 4 Number 2 March 2003

10th Conference on Retroviruses and Opportunistic Infections, 10-14 February 2003, Boston, USA

Bush plans $15 billion budget to treat two million people and prevent seven million infections in 14 countries – but meets criticism from activists

The World Health Organisation must continue its work on access to medicines in developing countries

Dr Jong-Wook Lee nominated to be WHO director-general

AAI Pharma access programme providing treatment for 36,000 people in Africa

Pharmacia to launch pilot programme for expanding access to medicines in the poorest countries

Heineken to offer antirerotviral drug coverage to African workforce

Five pharmaceutical companies to halve antiretroviral drug prices for central America

Patent law overrides would not expand access to drugs for low-income nations, opinion piece says

Efficacy and safety of a quadruple combination Combivir + abacavir + efavirenz regimen in antiretroviral treatment-naive HIV-1-infected adults: La Francilienne

Subtle decreases in stavudine (d4t, Zerit) phenotypic susceptibility predict poor virologic response to stavudine monotherapy in zidovudine (AZT, Retrovir)-experienced patients

Medical care providers have very limited knowledge of resistance-associated drug mutations

Inhibitory quotient useful as indicator of effective protease inhibitor therapy

30-year study links vitamin A to risk of fracture in humans

Bone turnover elevated in HIV-positive patients and linked to duration of HAART

Efavirenz effects worse than reported, study says

Protease inhibitors and cardiovascular outcomes in patients with HIV-1

HIV protease inhibitors promote atherosclerosis independent of dyslipidemia

HAART-associated hyperlipidaemia linked to low risk for cardiovascular disease (CVD)

Patient on human growth hormone develops tumours with growth hormone receptors

Review of trials shows testosterone increases lean body mass, and is most effective when given intramuscularly

Antiretroviral treatment increases adult thymic volume

Rituximab and chemotherapy is highly effective in patients with CD20-positive non-Hodgkin’s lymphoma and HIV

Lung cancer in HIV positive HAART-users

Functional MRI can find brain abnormalities in asymptomatic patients

Hepatitis C virus viraemia in HIV-positive individuals with negative HCV antibody tests

Roche’s Copegus (ribaviran) available in UK for use in the treatment of Hepatitis C

PEG-Intron plus ribavirin in non-responders and relapsers

Dangers of HIV/hepatitis B coinfection

SILCAAT IL-2 study saved as investigators take over responsibility and Chiron agrees to continue funding

Drug industry contributions influence clinical research, JAMA study says

Accuracy of pharmaceutical advertisements in medical journals

Lack of new drugs is reaching crisis point, says review

Medicines Control Agency must be more open

4th International Workshop on Adverse Drug Reactions and Lipodystrophy

Drug Development for Antiretroviral Therapies (DART) 2002

40th Annual Meeting of the Infectious Diseases Society of America

53rd Annual Meeting of the American Association for the Study of Liver Diseases (AASLD)

Medscape article including: Is there a pipeline? and AIDS articles in full

The Hopkins HIV Report, PRN Notebook, IAPAC, TAGline, IAVI Report

Spanish guidelines on management of HIV coinfection with Hepatitis A, B and C

Think tank explores liver transplants in HIV/AIDS

In HIV vaccine efforts, new strategies and patience are needed in equal measure

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