September 2022

Contents

Editorial

• HTB September 2022 (1 September 2022)

Special reports

• Update on monkeypox in the UK: reduced cases, vaccine access, transmission and treatment…

Conference reports

• 24th International AIDS Conference (AIDS 2022)

• Dolutegravir no longer linked to higher risk of neural tube defects: latest update from the Tsepamo study

• Weight gain with dolutegravir and TAF in ADVANCE study continues out to week 192

• VRC01 added to early ART in infants did not reduce viral reservoir

• Using PrEP during pregnancy is safe for children

• Long-acting CAB/RPV injections have a similar weight and lipid profile to dolutegravir-based oral ART

• Montreal’s response to monkeypox: rapid vaccine rollout, 39 breakthrough infections

• Summary of 620 cases of monkeypox seen at three London clinics

• Advances in HIV cure-related research: IAS workshop now online

Antiretrovirals

• Lenacapavir approved in the EU and UK to treat multidrug resistant HIV

mpox (monkeypox)

• US survey reports 50% of gay men changed sexual behaviour to avoid monkeypox

• US model limits monkeypox infections by one-third from having fewer one-time partners: short-term strategy until next vaccine supply

• BHIVA include efficacy data on HIV and monkeypox vaccine: updated statement (August 2022)

• Monkeypox DNA detected in anal samples of asymptomatic men in Paris and Belgium

• Unusual case reports: non-sexual acquisition, severe MPX and advanced HIV, human-to-dog transmission

• Tecovirimat for treating mild monkeypox: new studies open in the UK and US

• US cases: MMWR report on 1891 cases to 22 July 2022

• Monkeypox transmission in heterosexual couples in Nigeria

• Access to vaccines and treatment for pregnant women at risk of monkeypox

• MPX DNA easily detected on surfaces in hospital after cleaning

• Understanding HIV and monkeypox coinfection: NEAT/EACS dashboard

HIV prevention and transmission

• HIV seroconversions on PrEP in Australian study are linked to low adherence

PDFs

• HTB: no. 9 (3 September 2022) PDF download