HTB

Conference reports

Tuberculosis in HIV-positive children often missed from incidence data: the influence of HAART on paediatric TB

Nevirapine pharmacokinetics with infant prophylaxis

Prevention of rectal transmission of SIV in macaques using FTC with tenofovir: FTC has independent protective effect even as monotherapy

K65R frequently emerges within 1-6 weeks of tenofovir monotherapy in macaques

A genome armed against HIV

Circumcision: a surprising benefit from an unkind cut

Topical microbicides: the real front line of HIV prevention

Prevention of rectal transmission of SIV in macaques using FTC with tenofovir: FTC has independent protective effect even as monotherapy

Further reports from 13th Conference on Retroviruses and Opportunistic Infections (CROI), 5-8 February 2006, Denver

Pharmacokinetics of antiretrovirals in pregnancy: tenofovir, nelfinavir, lopinavir/r

Risk of central nervous system birth defects associated with ART exposure during pregnancy

No increase in adverse pregnancy outcomes in Thai women receiving nevirapine-containing HAART

ARV treatment following singe dose nevirapine exposure

Association of HIV replication capacity with mother to child transmission

Association between HIV subtype and detection of K103N

Pharmacology and drug interaction studies in adults: summary table from CROI, ICAAC and EACS conferences

Other new antiretrovirals at Denver: the future seems bright

Origins of HIV traced to chimpanzees in Cameroon

HSV-2 suppression reduces HIV and HSV shedding

13th Conference on Retroviruses and Opportunistic Infections (CROI), 5-8 February 2006, Denver

Early integrase inhibitor studies in treatment experienced patients raise hopes for new drugs in a new class

Atazanavir in treatment naive patients, with and without ritonavir boosting

Simplification to atazanavir/ritonavir monotherapy

Summary of STI studies: SMART shows clear increased risk from interrupting treatment at any CD4 count

The effect of repeated single-dose nevirapine for PMTCT in a second pregnancy

Should criteria for initiation of HAART be revisited in pregnant women?

Cotrimoxazole prophylaxis in pregnancy

Treatment in primary HIV infection

CNS penetration of ARV drugs is associated with lower CSF viral load

Sexual transmission of hepatitis C in HIV-positive men in the UK

D:A:D study shows that PIs rather than NNRTIs drive the previously reported cardiovascular risk of combination antiretroviral therapy

Interventions for the management of lipodystrophy and metabolic complications

45th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), 16-19 December 2005, Washington, USA

One third of HIV/HCV coinfected patients with normal ALT have advanced fibrosis in Spanish cohort

10th European AIDS Conference (EACS), 17-20 November 2005, Dublin, Ireland

Rifaximin cure reported for cryptosporidium in advanced HIV

Analysis of hepatic events in 2NN study by CD4 entry criteria, levels differences between nevirapine and efavirenz; excess hepatic events in once-daily nevirapine arm linked to single site in Thailand

FTC studies at EACS: reduced incidence of M184V compared to 3TC; side effect profile in clinical practice

Paediatric studies at EACS: trends in antiretroviral use in the Madrid Cohort; life expectancy significantly increased HIV/HCV co-infected children since HAART; use of tenofovir in treatment experienced children; switching to lopinavir/r from double protease inhibitor regimen; once daily lopinavir/r, 3TC and abacavir; planned treatment interruptions in children

Efficacy of lopinavir/r in patients with advanced HIV (CD4 <25 cells/mm3)

Potential barriers to use of T-20: results from patient and physician interviews

Factors associated with sexual dysfunction in HIV patients

Decreased varicella zoster immunity in migrants from sub-Saharan Africa

Clinical experience of switching to atazanavir in the UK’s largest clinic

Replacing a PI with atazanavir: separating swans from ducklings?

TMC 125: some good and bad news

When to change a failing regimen: second-line and salvage strategies

Antiretrovirals and other stuff!

Heart disease in people with HIV

Mortality trends: why people with HIV die (or don’t) today

45th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), 16-19 December 2005, Washington, USA

Understanding TMC114 power against resistant HIV

New antiretroviral compounds at ICAAC: new PI brecanavir from GSK; maturation inhibitor PA-457; antiviral activity of monoclonal antibody; TNX-355 in treatment experienced patients

Comparison of pharmacokinetics of originator and generic liquid formulations and split tablets in Malawian children

African-Americans in ACTG 5095 had shorter time to virologic failure and grade 3/4 side effects

Predictors of insulin resistance in first year of therapy

Three measures confirm 144-week renal record of tenofovir

Low rash risk with efavirenz after nevirapine rash

7th Workshop on Adverse Drug Reactions and Lipodystrophy in HIV, 13-16 November 2005, Dublin, Ireland

Monitoring side effects in resource limited countries

Uridine supplement reverses thymidine-induced lipoatrophy

Pravastatin increases limb fat in HIV-positive patients with hypercholesterolaemia

Evidence that facial fat can return after switching from either d4T or AZT, to abacavir or tenofovir

Niacin has beneficial effect on lipids but no reduction in abdominal fat

Gluteal implants used to replace lost buttock fat

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