New neonatal liquid formulations of dolutegravir have comparable bioavailability to dispersible paediatric tablet
11 November 2020. Related: Conference reports, Antiretrovirals, Paediatric care, PK and drug interactions.
Antiretrovirals
EMA issues positive opinion to approve cabotegravir LA/rilpivirine LA injections (Vocabria/Rekambys) as new HIV treatment
11 November 2020. Related: Antiretrovirals.
Capsid inhibitor lenacapavir, dosed six-monthly, has high barrier to drug resistance and no cross-resistance to other classes
14 October 2020. Related: Conference reports, Antiretrovirals.
Single doses of MK-8507 reduce viral load by mean –1.5 log and support once-weekly dosing above 80 mg
14 October 2020. Related: Conference reports, Antiretrovirals.
Capsid inhibitor lenacapavir (GS-6207) allows for 6-monthly dosing
28 August 2020. Related: Conference reports, Antiretrovirals.
US FDA approves dolutegravir/lamivudine (Dovato) as switch option
28 August 2020. Related: Antiretrovirals.
EMA extends indication for darunavir/r to include adolescents >12 years
28 August 2020. Related: Antiretrovirals.
ViiV resubmits cabotegravir plus rilpivirine long-acting injections (Cabenuva, Vocabria) to FDA for approval
28 August 2020. Related: Antiretrovirals.
ADVANCE 96-week results: dolutegravir weight gain continues, especially in women and when used with TAF – no evidence of a plateau
22 July 2020. Related: Conference reports, Antiretrovirals.
FDA approves fostemsavir (Rukobia) for multidrug resistant HIV in the US
22 July 2020. Related: Antiretrovirals.
FDA approves dolutegravir formulations to treat infants and young children
26 June 2020. Related: Antiretrovirals, Paediatric care.
Fit for purpose: antiretroviral treatment optimisation March 2020
12 March 2020. Related: Special reports, Supplements, Fit for purpose, Antiretrovirals.
Long-acting cabotegravir and rilpivirine injections support two-monthly dosing
12 March 2020. Related: Conference reports, Antiretrovirals.
Safety and PK of bNAb elipovimab (GS-9722) support two-weekly dosing
12 March 2020. Related: Conference reports, Antiretrovirals.
First results with long-acting capsid inhibitor GS-6207: oral and subcutaneous formulations for use in naïve and multidrug resistance
12 March 2020. Related: Conference reports, Antiretrovirals.
Long-acting cabotegravir and rilpivirine: similar results in women and men
24 February 2020. Related: Conference reports, Antiretrovirals, Women's health.
FDA decision on long-acting cabotegravir/rilpivirine (Cabenuva, Vocabria) injections delayed due to scale-up manufacturing problems
29 January 2020. Related: Antiretrovirals.
Fostemsavir submitted to EMA for treating multidrug resistant HIV
29 January 2020. Related: Antiretrovirals.
Gilead announces licensing agreement for Rockefeller University bNAbs
29 January 2020. Related: Antiretrovirals.
Capsid inhibitor GS-6207 (lenacapavir): potential for 6 monthly dosing for MDR HIV
13 December 2019. Related: Conference reports, Antiretrovirals.
Dolutegravir/lamivudine as dual ART
13 December 2019. Related: Conference reports, Antiretrovirals.
Weight changes with doravirine-based first line therapy
13 December 2019. Related: Conference reports, Antiretrovirals, Side effects.
Doravirine approved by NHS England as single NNRTI and as part of FDC with 3TC/TDF
13 December 2019. Related: Antiretrovirals.
Fostemsavir submitted to US FDA for multidrug resistant HIV
13 December 2019. Related: Antiretrovirals.
Paediatric dispersible formulation of dolutegravir submitted to EMA and FDA
13 December 2019. Related: Antiretrovirals.
Ibalizumab approved in the EU
15 November 2019. Related: Antiretrovirals.
HIV suppression and safety with ibalizumab at 48 weeks in expanded access
18 October 2019. Related: Conference reports, Antiretrovirals.
Oral cabotegravir and rilpivirine is durable for 5.5 years in LATTE study
18 October 2019. Related: Conference reports, Antiretrovirals.
Dolutegravir plus rilpivirine had good virologic, safety record in clinics before single tablet available
18 October 2019. Related: Conference reports, Antiretrovirals.
Switching from TDF to TAF linked to higher BMI and cardio risk
18 October 2019. Related: Conference reports, Antiretrovirals, Side effects.
Possible higher diabetes risk with raltegravir or PIs than NNRTIs
18 October 2019. Related: Conference reports, Antiretrovirals, Side effects.
Dual dolutegravir/lamivudine submitted to US FDA as switch option
18 October 2019. Related: Antiretrovirals.
Scotland approves dual therapy with dolutegravir/lamivudine (Dovato)
30 September 2019. Related: Antiretrovirals, Treatment access.
FDA expands indication for doravirine in the US as switch option
30 September 2019. Related: Antiretrovirals.
Switching to bictegravir/F/TAF in virally suppressed participants – including analyses by baseline drug resistance
23 August 2019. Related: Conference reports, Antiretrovirals.
Dolutegravir-based first-line non-inferior to efavirenz-based ART but associated with substantial weight gain: results from the ADVANCE study
23 August 2019. Related: Conference reports, Antiretrovirals, Treatment strategies, Side effects.
Cabotegravir/rilpivirine long-acting injectable HIV drugs submitted to EMA
23 August 2019. Related: Antiretrovirals.
First viral load results for capsid inhibitor GS-6207: mean –2.2 log reduction at day 10
24 July 2019. Related: Conference reports, Antiretrovirals.
Islatravir (MK-8591) with doravirine plus lamivudine: 24 week results
24 July 2019. Related: Conference reports, Antiretrovirals.
Dual therapy with islatravir (MK-8591) plus doravirine: 24 week results as switch strategy
24 July 2019. Related: Conference reports, Antiretrovirals.
Fostemsavir: 96-week follow-up in people with multi-drug resistance
24 July 2019. Related: Conference reports, Antiretrovirals.
Dolutegravir/lamivudine dual therapy non-inferior to triple ART at week-96
24 July 2019. Related: Conference reports, Antiretrovirals.
Switching to dolutegravir/lamivudine dual therapy is non-inferior to TAF-based triple therapy at week-48 in TANGO study
24 July 2019. Related: Conference reports, Antiretrovirals.
IAS 2019: late breaker highlights to look for
17 July 2019. Related: Conference reports, Antiretrovirals.
HIV pipeline report 2019
17 July 2019. Related: Special reports, Supplements, Pipeline report, Fit for purpose, Antiretrovirals.
Dolutegravir/lamivudine approved as dual HIV combination in EU
17 July 2019. Related: Antiretrovirals.
Dual long-acting cabotegravir/rilpivirine injection submitted to FDA
30 April 2019. Related: Antiretrovirals.
Dolutegravir/3TC dual FDC (Dovato) approved in the US and given positive opinion in the EU
30 April 2019. Related: Antiretrovirals.
Maturation inhibitor GSK’232 reduces viral load by –1.5 log at day 10
28 March 2019. Related: Conference reports, Antiretrovirals.
Capsid inhibitor GS-6207 shows potential for 3-monthly injections
28 March 2019. Related: Conference reports, Antiretrovirals.
First phase 1 results from bNAb PGT121 in HIV positive people
28 March 2019. Related: Conference reports, Antiretrovirals.
Dolutegravir/3TC dual ART is as effective at lowest viral load cut-off as triple therapy in GEMINI studies
28 March 2019. Related: Conference reports, Antiretrovirals, Treatment strategies.
Same-day ART is effective in San Francisco Rapid-ART clinic
28 March 2019. Related: Conference reports, Antiretrovirals, Treatment strategies.
Phase 3 results with dual therapy cabotegravir/rilpivirine long-acting injections: ATLAS and FLAIR studies
12 March 2019. Related: Conference reports, Antiretrovirals.
FDA approves generic TDF/3TC for use in the US
12 December 2018. Related: Antiretrovirals.
Doravirine (Pifeltro) and doravirine/TDF/3TC FDC (Delstrigo) approved in Europe
1 December 2018. Related: Antiretrovirals.
Viral dynamics of dolutegravir-based dual versus triple ART
13 November 2018. Related: Conference reports, Antiretrovirals.
Ibalizumab: 48-week phase 3 results in 27 participants with MDR HIV
13 November 2018. Related: Conference reports, Antiretrovirals.
Fostemsavir: 48-week phase 3 results from BRIGHTE study
13 November 2018. Related: Conference reports, Antiretrovirals.
Dolutegravir non-inferior to low dose efavirenz in real-life African study conducted in Cameroon
13 November 2018. Related: Conference reports, Antiretrovirals, Treatment strategies.
Dual bNAb maintains viral suppression for median 21 weeks off-ART
13 November 2018. Related: Conference reports, Antiretrovirals, Treatment strategies.
Cabotegravir levels can be detected several years: PK tail to be covered by oral PrEP
13 November 2018. Related: Conference reports, Antiretrovirals.
FDA updates rilpivirine label for use during pregnancy
13 November 2018. Related: Antiretrovirals.
Dolutegravir/lamividune FDC submitted to EMA and FDA
19 October 2018. Related: Antiretrovirals.
English court finds in favour of access to generic TDF/FTC
19 September 2018. Related: Antiretrovirals, HIV prevention and transmission, Other news.