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Conference reports

50th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), 12–-15 September 2010, Boston

Raltegravir pharmacokinetics inpregnancy

Low birth weight associated with HAART in pregnancy in Zambia

Bilirubin levels in infants following in utero atazanavir exposure compared to exposure to other antiretrovirals

Novel mutations and shifting susceptibility to darunavir and tipranavir

Four-drug single-pill antiretroviral equivalent to Atripla at 48 weeks

High rates of bone loss and progression with HIV in longitudinal study

XVIII International AIDS Conference: 18–-23 July 2010, Vienna

Spray-dried nanoparticle formulation of efavirenz

Switching boosted-PIs to raltegravir

Scaling up: what to do first?

A new point of care CD4 test

Early infant diagnosis

Efavirenz-based regimens among womenof reproductive age receiving ART in Johannesburg

Male circumcision retains effectiveness at reducing risk of HIV infection: 54 month results

Towards a cure: HIV reservoirs and strategies to control them, 16–17 July 2010, Vienna

Rapporteur summaries

XVIII International AIDS Conference: 18-–23 July 2010, Vienna

Navigating the IAS Vienna conference online

Results from the Caprisa 004 tenofovir microbicide trial

Quadrivalent HPV vaccine reduces genital lesions and HPV acquisition in men

Rilpivirine (TMC-278) vs efavirenz in treatment-naive patients: phase 3 results

Once-daily nevirapine extended release (XR) is non-inferior to current formulation

GSK572 (dolutegravir): second-generation integrase inhibitor

TBR-652: early results for CCR5 inhibitor

Atazanavir/r plus maraviroc or tenofovir/FTC in treatment-naive patients

Unboosted twice-daily atazanavir plus raltegravir

CASCADE analysis of when to start treatment

Impact of antiretroviral PMTCT prophylaxis regimens on subsequent maternal disease progression in Kesho Bora

Birth outcomes with antiretroviral exposure

New WHO guidelines for children (July 2010)

Early treatment for infants is cost-effective

No difference in outcomes for children initiating treatment with a protease inhibitor or an NNRTI nor with viral load switching strategies in PENPACT-1

Tablets more acceptable than syrups in the ARROW trial

Paediatric formulation of TMC 278

Smoking and atazanavir levels

Darunavir/ritonavir and rosuvastatin

Lime juice is not a microbicide: do not try at home

2nd Joint Conference of BHIVA with BASHH, 20–-23 April 2010, Manchester

HAART use among women in UK receiving treatment prior to conception

Duration of ruptured membranes and vertical transmission in the UK

Significant rates of unplanned pregnancies among young women born with HIV

Route of HCV transmission in HIV-positive gay men is unlikely to be from semen

75% HIV-positive children have insufficient levels of Vitamin D

Increase in LGV cases in gay men reported in the UK

High rates of osteopenia and osteoporosis: importance of DEXA monitoring

Summaries of other studies

11th International Workshop on Clinical Pharmacology of HIV Therapy, 7-9 April, 2010, Sorrento, Italy

Atazanavir absorption maximised with food

Methadone levels reduced moderately by rilpivirine

Maraviroc 150mg once-daily achieves target concentrations with atazanavir/ritonavir

Raltegravir and unboosted atazanavir

Raltegravir dose adjustment not required for patients on dialysis

Raltegravir and darunavir pharmacokinetics in liver disease

Tenofovir may require closer renal monitoring in older patients

Effect of age on atazanavir, darunavir, raltegravir and etravirine

Proposed approach to measuring TDM for raltegravir

Increased bilirubin levels when atazanavir is dosed twice-daily

17th Conference on Retroviruses and Opportunistic Infections (CROI) 16-19 February 2010, San Francisco

HIV reinfection cases reported at CROI

Hepatitis studies: IL28B genetics, HCV survival, FibroScan in acute HCV, MSM reinfection and responses to transplantation

Poor bioequivalence with crushed and dissolved tablets

Initial PK, safety and 12 week efficacy of raltegravir chewable tablets in children 6-11 years

PK of efavirenz in children dosed according to WHO weight bands

Virological and immunological responses in infants enrolled in the CHER trial

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