This booklet about changing HIV treatment and drug resistance was completely revised in February 2015.
It explains when and why treatment needs to be changed, which tests are used and what the results mean, how to choose drugs for the next combination and how to help make sure the next treatment will work well.
It also includes information about new drugs in development and other research.
- If your viral load never became undetectable…
- What to do if your viral load rebounds
- Viral load blips
- Confirmed viral rebound
- How can drugs “fail” when I feel fine?
- Viral load tests
- Resistance tests
- How to interpret resistance tests
- TDM (Therapeutic Drug Monitoring)
- IQ and VIQ
- Viral tropism
- Getting the tests in the UK
- General ideas or principles
- Cross-resistance by drug class
- When to use new drugs and when to wait?
- Pipeline drugs
- Expanded access drugs
- Non-ARV drugs
- Intensify treatment
- Using T-20
- Using five or more drugs
- Treatment interruptions
- Drug recycling using viral fitness
- Benefit of staying on treatment using drugs that are still active
This guide was written and compiled by Simon Collins for HIV i-Base. Thanks to the advisory group of HIV positive people and healthcare professionals for comments and to Monument Trust for funding this publication.
Information about how we produced this guide and the importance of using language that is direct and easy to understand.
This includes information on how to write non technical medical information that may be useful as a resource for other organisations.
1 February 2015