HTB

2006

Activists meet with Gilead and Abbott over access to second-line therapy

Data exclusivity: a new threat to affordable generic medicines

Updated US perinatal guidelines (2006)

Efficacy of treatment of acute hepatiitis C in patients with HIV infection

HIV transmission, the law and the work of the clinical team: draft recommendations for comment

FDA adds last minute clause into package of patient reforms that protects pharmaceutical industry from litigation in cases of side effects

Full journal articles with free access and online medical resources

Advocacy campaign tools online

Volume 7 Number 7/8 July/August 2006 PDF

Volume 7 Number 6 June 2006

7th International Workshop on Clinical Pharmacology of HIV Therapy, 20-22 April 2006, Lisbon

Efavirenz levels above recommended upper target in 20% of African patients in Senegal

Lower dose of AZT provides adequate exposure in patients with low body weight

Pharmacokinetics for generic fixed dose combinations for children are comparable to the branded products

Caution against dividing adult FDCs (Triomune) for young children

University of Liverpool audit of paediatric TDM

Age-dependent pharmacokinetics of 3TC in children

Use of small sample drug level monitoring for paediatric PI concentrations

Intracellular and plasma measurements of AZT and 3TC and their metabolites in neonates

Effect of pregnancy on PK of protease inhibitors

Using enzyme inducers to reduce the half-life of nevirapine

Relationship between nevirapine concentrations and virological failure in a clinical setting

Summary of drug interaction studies

Effects of ketoconazole and rifampin on TMC278

Brecanavir interaction study with ritonavir and atazanavir

Fixed-dose formulation of efavirenz/tenofovir/FTC bioequivalent to separate dosing

Saquinavir/r (1000/100mg) levels reduced when taken fasted and should be taken with food

Lack of food effect with Meltrex formulation of lopinavir/r

Food interaction reduces ddI intracellular absorption and supports requirement to take fasted

Conflicting results on how T-20 affects tipranavir

Autologous stem cells transplant (ASCT) in HIV-positive individuals with a relapsed non-Hodgkin’s lymphoma (NHL) or Hodgkin’s disease (HD)

US adult treatment guidelines updated (May 2006)

Draft BHIVA immunisation guidelines online (2006)

ITPC publish updated report on access to treatment

Protesters evicted from UN headquarters, New York

Community opposition filed against tenofovir patent application in India

Web resources for HIV-1 genotypic-resistance test interpretation

HIV linked to lower rifampin and ethambutol AUCs in TB cohort

LGV in the UK: almost 350 cases reported and still predominantly affecting HIV-positive gay men

Conference abstracts and reports

HIV InSite: new chapters

PLoS Medicine articles

New HIV vaccine website

Volume 7 Number 6 June 2006 PDF

Volume 7 Number 5 May 2006

Letter from Sir Liam Donaldson to all Chief Executives of Primary Care Trusts and Strategic Health Authorities in England

12th Annual Conference of the British HIV Association, 29 March–-1 April 2006, Brighton

HIV in the UK – summaries from BHIVA 12th annual conference

Primary care practice still fails to diagnose HIV patients from high-risk groups or with symptomatic acute infection

Use of HLA-B*5701 genetic testing to reduce abacavir hypersensitivity reactions

Dosing rifabutin and lopinavir/r – sub-optimal rifabutin levels reported in five patients dosed according to current guidelines

Fatal seronegative visceral leishmaniasis in Portuguese patient

Awareness of PEP after sexual exposure (PEPSE)

Final reports from 13th Conference on Retroviruses and Opportunistic Infections (CROI), 5-8 February 2006, Denver

Regimen durability and toxicity in 36-month follow up on ART in Khayelitsha, South Africa

Adults in resource-limited settings are most likely to experience an HIV-associated Illness in the first three months from initiating therapy

Causes of death in adults receiving ARV therapy in Senegal

Rapid scale-up of treatment in Zambia delivered at primary health level

The effect of HIV subtype on disease progression in Rakai, Uganda

Genital tract pharmacokinetics of ten antiretroviral drugs in HIV-positive women

Initiation of ART leads to a rapid decline in cervical and vaginal HIV-1 RNA

Effect of HSV-2 treatment on HIV-1 genital shedding and plasma viral load

Once-daily FTC, ddI, and efavirenz in children and adolescents

Simplified triple NRTI regimen effective in vertically infected children: two years follow-up

Long-term clinical and biological outcomes in children vertically infected with HIV

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