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Conference reports

5th HIV Persistence Workshop on HIV Reservoirs, 6-9 December 2011, West Indies

Workshop report and commentary: HIV persistence and reservoirs

13th European AIDS Conference (EACS), Belgrade, Serbia, 12-15 October 2011

European guidelines (EACS) – 2011 update

Raltegravir achieves superiority over efavirenz after four years

Higher plasma levels of tenofovir and darunavir but not efavirenz in older patients

Ritonavir levels reduced with high fat meal

Transplacental transfer of raltegravir and delayed plasma clearance in preterm neonates

2nd International Workshop on HIV and Ageing, Baltimore, Maryland, 27-28 October 2011

Statin blocks negative impact of PIs on bone formation in vitro

HIV linked to frailty in middle-aged IDUs, especially with poor HIV control

51st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) Chicago, 17-20 September 2011

Monitoring kidney function change with cobicistat

Intracellular raltegravir concentrations better with twice-daily than once-daily dosing

6th IAS Conference on HIV Pathogenesis, Treatment and Prevention, 17-20 July 2011, Rome

Cure research and viral reservoirs

Orange Farm circumcision results dispel concerns about risk compensation

Randomised trial of ART in TB patients with high CD4 counts

6th IAS Conference on HIV Pathogenesis, Treatment and Prevention 17-–20 July 2011, Rome

Webcasts for major research at IAS

Treatment is prevention: ARV treatment in HPTN-052 reduces transmission by at least 96%: single transmission in treatment arm occurred before viral suppression

Daily oral tenofovir/FTC PrEP reduces heterosexual transmission by 63% in the TDF2 study

Tenofovir/FTC vs tenofovir as daily oral PrEP: preliminary results from Partners PrEP

Elvitegravir vs raltegravir: 48 week results in treatment-experienced patients

Dolutegravir: 48 week results from phase II study in treatment-naive patients

Lersivirine: 48 week results compared to efavirenz in phase 2 treatment-naive study

Maraviroc plus atazanavir/r without nukes versus standard of care: 48 week results

SPARTAC trial: treatment in primary infection for 48 weeks shows small delay in disease progression

Hearing loss not associated with HIV in MACS and WIHS cohorts

Pharmacokinetics of darunavir and fosamprenavir in pregnancy

Low birth weight and preterm delivery

Hormonal contraception and HIV transmission risk

No difference in AIDS-free survival in children starting ART with a CD4% between 15%–24% compared to deferring until less than 15% in the PREDICT trial

Paediatric antiretroviral pipeline: update on etravirine and maraviroc

Prematurity not associated with early mortality in infants on ART

More metabolic abnormalities in children receiving a PI compared to NNRTI in NEVEREST study

Free online resource for treatment decisions without access to genotype resistance tests

17th Annual Conference of the British HIV Association (BHIVA) 6-8 April 2011, Bournemouth

Treatment in seroconversion maintains HIV specific immune responses similar to long term slow progressors

18th Conference on Retroviruses and Opportunistic Infections (CROI) 27 February-–3 March 2011, Boston

Monitoring treatment in resource limited settings: results from PHPT-3 and Stratall ANRS12110/ESTER trials

DART: high rates of viral suppression after five years and a single CD4 test with a threshold of 250 cells/mm3 could reduce unnecessary switching

Lopinavir/r monotherapy used as second-line therapy in resource-limited settings

Treating children previously exposed to single dose nevirapine: update on IMPAACT P1060 and NEVEREST

Lopinavir/ritonavir oral solution toxicity in neonates

Paediatric antiretroviral pipeline: darunavir and raltegravir

Pharmacokinetics of different rifabutin dosing strategies with lopinavir/ritonavir-based ART

Initiation of ART during breastfeeding can induce multidrug resistance in infants

First Workshop on Nanomedicine for Infectious Diseases of Poverty, 27-31 March 2011, Magaliesberg, South Africa

17th Annual Conference of the British HIV Association (BHIVA), 6-8 April 2011, Bournemouth

Atazanavir in pregnancy: 155 cases in London clinics

Co-morbidity and late presentation – findings from an over 50s cohort

Health outcomes for young adults with perinatally acquired HIV infection following transfer to adult services

The use of calcaneal stiffness index to screen for osteoporosis in HIV-infected individuals

Frequency and characteristics of long-term non-progressors and HIV controllers in the Chelsea and Westminster cohort

Cerebral function in perinatally HIV infected young people and HIV uninfected sibling controls

An audit of HIV care provision for Immigration Removal Centre patients

12th International Workshop on Clinical Pharmacology of HIV Therapy, 13–-15 April 2011, Miami

Quad reduces levels of oral contraceptives

Elvitegravir/cobicistat and acid reducing agents

Lopinavir/r reduces levels of rifabutin

Cobicistat has little impact on CYP2D6 and CYP2B6

Atazanavir levels indicate need for higher dose during pregnancy

Etravirine lowers levels of maraviroc given at 300 or 600 mg twice daily

Once-daily 150-mg maraviroc explored in people taking atazanavir/ritonavir

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