HTB

Antiretrovirals

Ibalizumab approved in the EU

HIV suppression and safety with ibalizumab at 48 weeks in expanded access

Oral cabotegravir and rilpivirine is durable for 5.5 years in LATTE study

Dolutegravir plus rilpivirine had good virologic, safety record in clinics before single tablet available

Switching from TDF to TAF linked to higher BMI and cardio risk

Possible higher diabetes risk with raltegravir or PIs than NNRTIs

Dual dolutegravir/lamivudine submitted to US FDA as switch option

Scotland approves dual therapy with dolutegravir/lamivudine (Dovato)

FDA expands indication for doravirine in the US as switch option

Switching to bictegravir/F/TAF in virally suppressed participants – including analyses by baseline drug resistance

Dolutegravir-based first-line non-inferior to efavirenz-based ART but associated with substantial weight gain: results from the ADVANCE study

Cabotegravir/rilpivirine long-acting injectable HIV drugs submitted to EMA

First viral load results for capsid inhibitor GS-6207: mean –2.2 log reduction at day 10

Islatravir (MK-8591) with doravirine plus lamivudine: 24 week results

Dual therapy with islatravir (MK-8591) plus doravirine: 24 week results as switch strategy

Fostemsavir: 96-week follow-up in people with multi-drug resistance

Dolutegravir/lamivudine dual therapy non-inferior to triple ART at week-96

Switching to dolutegravir/lamivudine dual therapy is non-inferior to TAF-based triple therapy at week-48 in TANGO study

IAS 2019: late breaker highlights to look for

Dolutegravir/lamivudine approved as dual HIV combination in EU

Dual long-acting cabotegravir/rilpivirine injection submitted to FDA

Dolutegravir/3TC dual FDC (Dovato) approved in the US and given positive opinion in the EU

Maturation inhibitor GSK’232 reduces viral load by –1.5 log at day 10

Capsid inhibitor GS-6297 shows potential for 3-monthly injections

First phase 1 results from bNAb PGT121 in HIV positive people

Dolutegravir/3TC dual ART is as effective at lowest viral load cut-off as triple therapy in GEMINI studies

Same-day ART is effective in San Francisco Rapid-ART clinic

Phase 3 results with dual therapy cabotegravir/rilpivirine long-acting injections: ATLAS and FLAIR studies

FDA approves generic TDF/3TC for use in the US

Doravirine (Pifeltro) and doravirine/TDF/3TC FDC (Delstrigo) approved in Europe

Viral dynamics of dolutegravir-based dual versus triple ART

Ibalizumab: 48-week phase 3 results in 27 participants with MDR HIV

Fostemsavir: 48-week phase 3 results from BRIGHTE study

Dolutegravir non-inferior to low dose efavirenz in real-life African study conducted in Cameroon  

Dual bNAb maintains viral suppression for median 21 weeks off-ART

Cabotegravir levels can be detected several years: PK tail to be covered by oral PrEP

FDA updates rilpivirine label for use during pregnancy

Dolutegravir/lamividune FDC submitted to EMA and FDA

English court finds in favour of access to generic TDF/FTC

FDA approves doravirine (Pifeltro) and new FDC with TDF/3TC (Delstrigo) in the US

FDA update labels for dolutegravir and dolutegravir-based FDCs to reflect potential risk of neural tube defects

Top-line phase 3 results released for cabotegravir/rilpivirine long-acting injections

Interactions between oral anticoagulants and Genvoya, Stribild and cobicistat: FDA label updates

DTG/3TC dual therapy is non-inferior to triple-ART in GEMINI study

Superior efficacy with dolutegravir-based ART compared with other regimens at 6 months: real-world data from Brazil 

Featured Fit for purpose: Antiretroviral treatment optimisation

Featured HIV pipeline 2018: full version

Bictegravir/FTC/TAF (Biktarvy) approved in Europe

New contraindication against using darunavir/cobicistat during pregnancy

China approves albuvirtide: a once-weekly injectable entry inhibitor

Single dose PRO140 mAb reduces viral load by 0.5 log copies/mL in people with multidrug resistance

EMA approves dolutegravir/rilpivirine (Juluca) in Europe as dual-therapy HIV switch option

Meta-analysis of TAF vs TDF in boosted vs unboosted regimens

Meta-analysis of dolutegravir in naive, experienced and switch studies

Drug cost savings from routine use of generic ARVs: safety and efficacy in practice

Ibalizumab 24-week phase 3 results and susceptibility to drug-resistant HIV

Bictegravir at CROI 2018: switching studies and drug resistance analyses

FDA approves ibalizumab in the US to treat multidrug HIV resistance

FDA grants tentative approval to first DTG/FTC/TAF FDC

Bictegravir approved in the US in new integrase-inhibitor based FDC (Biktarvy)

US approve a lower-dose efavirenz (400 mg) based generic FDC (Simfi Lo)

ViiV announces phase 3 study switching to dolutegravir/3TC dual therapy from TAF-containing ART

US darunavir label updated: drug interactions and pregnancy

Doravirine FDC submitted to FDA in US: decision expected October 2018

FDA approves raltegravir for newborns

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