Switching to bictegravir/F/TAF in virally suppressed participants – including analyses by baseline drug resistance

Dolutegravir-based first-line non-inferior to efavirenz-based ART but associated with substantial weight gain: results from the ADVANCE study

Cabotegravir/rilpivirine long-acting injectable HIV drugs submitted to EMA

First viral load results for capsid inhibitor GS-6207: mean –2.2 log reduction at day 10

Islatravir (MK-8591) with doravirine plus lamivudine: 24 week results

Dual therapy with islatravir (MK-8591) plus doravirine: 24 week results as switch strategy

Fostemsavir: 96-week follow-up in people with multi-drug resistance

Dolutegravir/lamivudine dual therapy non-inferior to triple ART at week-96

Switching to dolutegravir/lamivudine dual therapy is non-inferior to TAF-based triple therapy at week-48 in TANGO study

IAS 2019: late breaker highlights to look for

Dolutegravir/lamivudine approved as dual HIV combination in EU

Dual long-acting cabotegravir/rilpivirine injection submitted to FDA

Dolutegravir/3TC dual FDC (Dovato) approved in the US and given positive opinion in the EU

Maturation inhibitor GSK’232 reduces viral load by –1.5 log at day 10

Capsid inhibitor GS-6297 shows potential for 3-monthly injections

First phase 1 results from bNAb PGT121 in HIV positive people

Dolutegravir/3TC dual ART is as effective at lowest viral load cut-off as triple therapy in GEMINI studies

Same-day ART is effective in San Francisco Rapid-ART clinic

Phase 3 results with dual therapy cabotegravir/rilpivirine long-acting injections: ATLAS and FLAIR studies

FDA approves generic TDF/3TC for use in the US

Doravirine (Pifeltro) and doravirine/TDF/3TC FDC (Delstrigo) approved in Europe

Viral dynamics of dolutegravir-based dual versus triple ART

Ibalizumab: 48-week phase 3 results in 27 participants with MDR HIV

Fostemsavir: 48-week phase 3 results from BRIGHTE study

Dolutegravir non-inferior to low dose efavirenz in real-life African study conducted in Cameroon  

Dual bNAb maintains viral suppression for median 21 weeks off-ART

Cabotegravir levels can be detected several years: PK tail to be covered by oral PrEP

FDA updates rilpivirine label for use during pregnancy

Dolutegravir/lamividune FDC submitted to EMA and FDA

English court finds in favour of access to generic TDF/FTC

FDA approves doravirine (Pifeltro) and new FDC with TDF/3TC (Delstrigo) in the US

FDA update labels for dolutegravir and dolutegravir-based FDCs to reflect potential risk of neural tube defects

Top-line phase 3 results released for cabotegravir/rilpivirine long-acting injections

Interactions between oral anticoagulants and Genvoya, Stribild and cobicistat: FDA label updates

DTG/3TC dual therapy is non-inferior to triple-ART in GEMINI study

Superior efficacy with dolutegravir-based ART compared with other regimens at 6 months: real-world data from Brazil 

Featured Fit for purpose: Antiretroviral treatment optimisation

Featured HIV pipeline 2018: full version

Bictegravir/FTC/TAF (Biktarvy) approved in Europe

New contraindication against using darunavir/cobicistat during pregnancy

China approves albuvirtide: a once-weekly injectable entry inhibitor

Single dose PRO140 mAb reduces viral load by 0.5 log copies/mL in people with multidrug resistance

EMA approves dolutegravir/rilpivirine (Juluca) in Europe as dual-therapy HIV switch option

Meta-analysis of TAF vs TDF in boosted vs unboosted regimens

Meta-analysis of dolutegravir in naive, experienced and switch studies

Drug cost savings from routine use of generic ARVs: safety and efficacy in practice

Ibalizumab 24-week phase 3 results and susceptibility to drug-resistant HIV

Bictegravir at CROI 2018: switching studies and drug resistance analyses

FDA approves ibalizumab in the US to treat multidrug HIV resistance

FDA grants tentative approval to first DTG/FTC/TAF FDC

Bictegravir approved in the US in new integrase-inhibitor based FDC (Biktarvy)

US approve a lower-dose efavirenz (400 mg) based generic FDC (Simfi Lo)

ViiV announces phase 3 study switching to dolutegravir/3TC dual therapy from TAF-containing ART

US darunavir label updated: drug interactions and pregnancy

Doravirine FDC submitted to FDA in US: decision expected October 2018

FDA approves raltegravir for newborns

Fostemsavir in highly treatment-experienced participants: 24-week phase 3 results

D/C/F/TAF: phase 3 naive results and splitting PI-based FDC tablets

Switch study shows F/TAF non-inferior to continuing abacavir/3TC

No impact on bioavailability of D/C/F/TAF when tablet is split but TAF absorption is reduced if crushed

ABX464 nudges viral reservoir but not time to viral rebound

Long-acting ART for children is a deferred priority despite achievable dosing

Coformulated dolutegravir plus rilpivirine approved in US (Juluca)

Darunavir-based single pill FDC approved in EU (Symtuza)

Dual therapy with darunavir/r plus lamivudine as first-line ART

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