HTB

Conference reports

Studies highlight problems of rectal disease in HIV-positive patients

9th Annual British HIV Association Conference (BHIVA), 24-26 April 2003, Manchester

UK 2003 audit and national standards of care

Outline of changes to UK 2003 guidelines for treating HIV in adults

Gender differences in rates and reasons for stopping treatment

Maternal health, transmission and fertility

Women: sexual function and relationships

Paediatrics: neurological and developmental outcomes

The impact of migration, race and ethnic diversity on healthcare delivery and clinical outcomes in the UK

High levels of gout may be linked to HAART

4th International Workshop on Clinical Pharmacology of HIV Therapy, 27-29 March 2003, Cannes, France

Can low NVP plasma concentrations explain the results seen in the EFV and NVP containing arms of the NARVAL study?

Up to one third of patients receiving standard doses of NNRTIs may be being underdosed

Nelfinavir concentrations are significantly higher in HIV/HCV co-infected patients with cirrhosis

Less diarrhoea and bioequivalence with the new nelfinavir 625mg tablet

The potential for probenecid to have a serious interaction with HIV-1 protease inhibitors

PK studies reveal significant sex/gender differences

Pregnancy-related PK studies

New test to measure intracellular levels of nucleosides

Case studies for therapeutic drug monitoring (TDM)

Launch of guide to the use of drug level monitoring

10th Conference on Retroviruses and Opportunistic Infections (CROI), 10-14 February 2003, Boston, USA

Pharmacokinetic papers from 10th CROI

Pediatric studies from 10th CROI

10th Conference on Retroviruses and Opportunistic Infections (CROI), 10-14 February 2003, Boston, USA

Pipeline compounds in Phase 2/3 Studies

96-week results show tenofovir-including regimen has side-effect advantages over d4T regimen in treatment naïve patients

2NN results – nevirapine and efavirenz in prospective randomised head-to-head study

NIH/NIAID study of generic drugs shows results consistent with stringent manufacturing standards

Treatment interruptions: cycles, pauses, are just plain stopping?

Conference has strong emphasis on women

Tenofovir and renal tubular dysfunction

Approaches to treatment of lipodystrophy

Surgery for buffalo hump shows variable results depending on method

Other studies – nucleosides and switching to abacavir; importance of lipoatrophy and buffalo hump

HAART to HEART: cardiovascular risk in HIV

Alendronate, vitamin D and calcium are safe and effective treatment for HIV-associated bone loss

Bone loss and fat loss are closely related in HIV patients on HAART

Low dose 200/100 IDV/RTV managed by TDM in substudy of co-infected patients

12-week response predicts which HIV-HCV coinfected patients will not benefit from continued pegylated interferon plus ribavirin

Pegylated interferon associated with eye disorders

Nevirapine resistance – the cautionary tales continue

10th Conference on Retroviruses and Opportunistic Infections, 10-14 February 2003, Boston, USA

6th International Congress on Drug Therapy in HIV Infection, 17-21 November 2002, Glasgow, UK

Combination of three generic drugs in one pill meets bioequivalence criteria when compared with the branded drugs: Triomune vs d4T/3TC/NVP

An overview of the conference

Pharmacokinetic evaluation of tenofovir and enteric-coated ddI

The advantages of fosamprenavir; comparing saquinavir/r to lopinavir/r; reducing viral load to <3 copies; AZT-d4T cross resistance; and rising HCV rates

Promising data regarding DermaVir for therapeutic vaccine

Enfuvirtide (T-20): predicting success and modelling survival benefits

Virologic failure among treatment-naive patients taking tenofovir DF or stavudine in combination with lamivudine and efavirenz

Comparison of the efficacy and safety of tenofovir vs. d4T when used in combination with 3TC and efavirenz in ARV-naive patients

Safety profile of tenofovir in treatment-experienced patients

42nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), San Diego, 27-30 September 2002

Immunology and treatment interruption data presented at the 42nd ICAAC

Treatment interruptions may result in poor T-cell recovery in patients with nadir CD+ count <50 cells/mm3

Treatment interruptions are safe in patients with CD4+ count between 300 to 500 cells/mm3 and viral loads lower than 70,000 copies/mL

Topical transdermal testosterone gel offers significant clinical benefits in hypogonadal HIV-positive patients

BMS experimental PI atazanavir shows potency comparable to NNRTI efavirenz among treatment-naïve HIV patients

Adverse drug reactions and lipodystrophy in children

Study suggests Kaletra/Combivir is better tolerated PEP than Combivir/nelfinavir

Novel approaches to the inhibition of HIV

Lipodystrophy and adverse drug reaction data presented at the 42nd ICAAC

4th International Workshop on Drug Reactions and Lipodystrophy in HIV Infection, San Diego, 22-25 September 2002

Leptin, lipodystrophy and insulin resistance

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