HTB

2014

US adult treatment guidelines updated (May 2014)

US PrEP guidelines (May 2014): emphasis on broad access may miss optimal use by people at highest risk

Incidence of HIV dual infections in US men who have sex with men

Reassessing the role of HDAC inhibitors in cure research

More on the links between the CD4/CD8 ratio, immunological perturbations, and risk of illness and death

EMA fast-track sofosbuvir/ledipasvir FDC for hepatitis C

Partner 2 study extended for gay couples

TAILoR Study: telmisartan to reduce risk of insulin resistance: potential role for lipodystrophy

SCART study: selumetinib as potential treatment for HIV-related KS

Scotland agrees to free HIV treatment, regardless of residency status

Volume 15 Number 5/6 May/June 2014 PDF

Community reports and briefings

March/April 2014: Volume 15 Number 3/4

21st Conference on Retroviruses and Opportunistic Infections (CROI), 3-6 March 2014, Boston

No HIV transmissions with undetectable viral load: interim PARTNER study results show need for longer follow-up

PrEP injections every three months may protect against exposure from anal sex

ARV pipeline: doravirine, GSK-744 and BMS-068

Viral load rebound rate of 35% using ritonavir-boosted PI monotherapy: results of five-year PIVOT study

Dual therapy less effective at high viral load: NEAT 001 study with raltegravir/darunavir/r

Atazanavir, raltegravir and darunavir virologically equivalent in naive patients but significant differences for tolerability: results from ACTG 5257

Pharmacokinetic targets for efavirenz might be too high

Abacavir link to cardiovascular events in high-risk patients maintained in D:A:D study

NNRTI resistance found in 12% of people stopping treatment with undetectable viral load: implications for stock-outs

HIV related infections remain the leading cause of maternal deaths in South Africa despite the availability of ART

Lower newborn bone mineral content with maternal tenofovir use

Paediatric pipeline: CROI 2014 update on new antiretrovirals for children

Efavirenz maintenance therapy effective in children exposed to nevirapine prophylaxis

Xpert TB test has important advantages but does not reduce morbidity

Reports of a second baby possibly cured of HIV: uncertainty remains

Updates on SB728-T, a CCR5-targeting gene therapy

FDA approvals of generic ARVS

UK guidelines for HIV-related cancers (2014): published online

Draft BHIVA pregnancy guidelines (2014) online for comment

Strong recommendations in WHO 2014 guidelines are often based on lower quality evidence than indicated in GRADE approach

FDA approves raltegravir for children older than 4 weeks

The prognostic value of interleukin-6 and D-dimer levels in primary HIV infection

HIV reservoir: CD4 T stem cells may facilitate long-term persistence

Update published on the first Berlin patient

Poor CD4 T cell recovery despite HIV suppression linked to increased morbidity and mortality

The relevance of the CD4/CD8 ratio in the ART era

First human trial of AAV as a delivery vehicle for HIV neutralising antibodies gets underway

Pharma refuses to ensure access to lifesaving hepatitis C treatment at global meeting

New treatments for HCV: strategies for achieving universal access

Conference resources

Volume 15 Number 3/4 March/April 2014 PDF

Online articles

Volume 15 Number 1/2 January/February 2014 PDF

January/February 2014: Volume 15 Number 1/2

4th International Workshop on HIV & Women, 13-14 January 2014, Washington

Women, HIV research and antiretrovirals

Improved virological outcomes for women starting efavirenz-based first-line regimens in South Africa

High rates of pregnancy in HIV positive women in Zambia and South Africa

Contraceptive choices among a Canadian cohort of HIV positive women

Bone disease and older HIV positive women

Lower immune response to the qHPV vaccine in HIV positive girls

HIV exposed vs unexposed babies have lower gestational age and birth weight in Danish study

Outcomes in infants exposed to lopinavir/ritonavir in utero

17th International Conference on AIDS and STIs in Africa (ICASA), 7-11 December 2013, Cape Town

Two percent rate of efavirenz discontinuation in an ART programme in Malawi

6th International Workshop on HIV Persistence During Therapy, 3-6 December 2013, Miami, USA

Report from the 6th Workshop on HIV Persistence

Dolutegravir approved in Europe

BMS to add atazanavir to Patent Pool

Donors pledge $12 billion to Global Fund for 2014–2016: increase still short of $15 billion goal

Global Fund and UNAIDS urge Nigeria to reconsider new anti-gay law

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