HIV treatment bulletin

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Treatment strategies

• Treatment in seroconversion maintains HIV specific immune responses similar to long term slow progressors Basic science and immunology - Conference reports - Treatment strategies - BHIVA 17th Bournmouth 2011 - 1 August 2011

• Monitoring treatment in resource limited settings: results from PHPT-3 and Stratall ANRS12110/ESTER trials Conference reports - Treatment access - Treatment strategies - CROI 18 (Retrovirus) 2011 - 1 August 2011

• DART: high rates of viral suppression after five years and a single CD4 test with a threshold of 250 cells/mm3 could reduce unnecessary switching Conference reports - Treatment access - Treatment strategies - CROI 18 (Retrovirus) 2011 - 1 August 2011

• Lopinavir/r monotherapy used as second-line therapy in resource-limited settings Conference reports - Treatment access - Treatment strategies - CROI 18 (Retrovirus) 2011 - 1 August 2011

• Dose optimisation: 50 mg ritonavir-boosting, 3TC dosing and raltegravir once-daily Antiretrovirals - Conference reports - Treatment strategies - PK Workshop 12th 2011 - 1 May 2011

• Switching boosted-PIs to raltegravir Antiretrovirals - Conference reports - Treatment strategies - World AIDS 18 Vienna 2010 - 1 October 2010

• Scaling up: what to do first? Conference reports - Guidelines - Treatment strategies - World AIDS 18 Vienna 2010 - 1 October 2010

• Tablets more acceptable than syrups in the ARROW trial Antiretrovirals - Conference reports - Paediatric care - Treatment strategies - World AIDS 18 Vienna 2010 - 26 August 2010

• Current or former injecting drug use is not related to earlier switch or discontinuation of HAART compared to non-IDU patients since 1999 Treatment strategies - 2 October 2007

• HIV viraemia may explain increased risk of cardiovascular disease, death and other serious events in patients interrupting treatment in the SMART trial: new study to randomise patients with CD4 counts >500 to start immediate treatment or defer to <350 cells/mm3 Conference reports - Treatment strategies - IAS 4 Sydney 2007 - 3 September 2007

• CD4 increases in immunological non-responders despite suppressive therapy following switch to nuke-sparing regimen of ATZ/SQV/r Conference reports - Treatment strategies - IAS 4 Sydney 2007 - 3 September 2007

• Autologous stem cells transplant (ASCT) in HIV-positive individuals with a relapsed non-Hodgkin’s lymphoma (NHL) or Hodgkin’s disease (HD) Special reports - Treatment strategies - 10 June 2006

• Treatment interuption arm in DART trial is stopped early Treatment strategies - 10 April 2006

• Simplification to atazanavir/ritonavir monotherapy Conference reports - Treatment strategies - CROI 13 (Retrovirus) 2006 - 25 March 2006

• Summary of STI studies: SMART shows clear increased risk from interrupting treatment at any CD4 count Conference reports - Treatment strategies - CROI 13 (Retrovirus) 2006 - 25 March 2006

• Treatment in primary HIV infection Conference reports - Treatment strategies - CROI 13 (Retrovirus) 2006 - 25 March 2006

• Therapeutic vaccinations and treatment interruptions Treatment strategies - 7 March 2006

• Improved clinical outcome in 80% patients who modified an NNRTI or PI dose following therapeutic drug monitoring (TDM) Antiretrovirals - Treatment strategies - 13 December 2005

• Another chance for 3TC in patients with M184V mutation? Antiretrovirals - Conference reports - Resistance - Treatment strategies - World AIDS 15 Bangkok 2004 - 6 September 2004

• Kaletra monotherapy: small studies and early data Antiretrovirals - Conference reports - Treatment strategies - World AIDS 15 Bangkok 2004 - 6 September 2004

• Interruption of treatment is safe for those who started too early Conference reports - Treatment strategies - EACS 9 Warsaw 2003 - 1 December 2003

• STIs in resource limited settings Conference reports - Treatment strategies - ICASA 13th 2003 - 1 November 2003

• Studies and strategies with existing drugs Antiretrovirals - Conference reports - Treatment strategies - ICAAC 43rd Chicago 2003 - 1 November 2003

• Treatment interruption prior to five-drug regime shows no benefit at 48 weeks Treatment strategies - 1 November 2003

• Failure of alternating week-on and week-off therapy Treatment strategies - 1 November 2003

• Treatment interruption shows no benefit in drug-resistant HIV infection Treatment strategies - 1 October 2003

• Treatment interruption: a real choice Conference reports - Lipodystrophy and metabolic complications - Treatment strategies - Lipodystrophy Workshop (IWADRW) 5 Paris 2003 - 1 September 2003

• Nucleoside-sparing regimens Antiretrovirals - Conference reports - Treatment strategies - IAS 2 Paris 2003 - 1 September 2003

• Lessons learned from early HAART in acute HIV infection Antiretrovirals - Conference reports - Treatment strategies - 1 September 2003

• Gender differences in rates and reasons for stopping treatment Conference reports - Treatment strategies - Women's health - BHIVA 9th Manchester 2003 - 1 June 2003

• Immune reconstitution in older HIV-positive individuals Antiretrovirals - Treatment strategies - 1 May 2003

• Treatment interruptions: cycles, pauses, are just plain stopping? Antiretrovirals - Conference reports - Treatment strategies - CROI 10 (Retrovirus) 2003 - 1 April 2003

• The advantages of fosamprenavir; comparing saquinavir/r to lopinavir/r; reducing viral load to <3 copies; AZT-d4T cross resistance; and rising HCV rates Antiretrovirals - Conference reports - Hepatitis coinfection - Resistance - Treatment strategies - HIV 6 Glasgow 2003 - 1 February 2003

• Immunology and treatment interruption data presented at the 42nd ICAAC Conference reports - Treatment strategies - ICAAC 42nd San Diego 2002 - 13 November 2002

• Treatment interruptions may result in poor T-cell recovery in patients with nadir CD+ count <50 cells/mm3 Conference reports - Treatment strategies - ICAAC 42nd San Diego 2002 - 13 November 2002

• Treatment interruptions are safe in patients with CD4+ count between 300 to 500 cells/mm3 and viral loads lower than 70,000 copies/mL Conference reports - Treatment strategies - ICAAC 42nd San Diego 2002 - 13 November 2002

• Treatment interruption strategy reports from the XIV International AIDS Conference Conference reports - Treatment strategies - World AIDS 14 Barcelona 2002 - 11 September 2002

• Aminoperazine shows promise in enhancing immune response of HIV patients Treatment strategies - 1 October 2001

• Interleukin-2 with dual nucleoside therapy Treatment strategies - 1 October 2001

• Immunotherapy at the 1st IAS conference Treatment strategies - 1 September 2001

• Outcome of patients with discordant responses to HAART Antiretrovirals - Treatment strategies - 17 May 2001

• Preliminary data from four studies of double PI regimen using once daily Fortovase plus “mini dose” ritonavir Antiretrovirals - Treatment strategies - PK Workshop 2nd 2001 - 17 May 2001

• Interleukin-2 improves CD4+ cell counts in patients with poor immune response to HAART Treatment strategies - 17 April 2001

• Use of cytokines in HIV: colony-stimulating factors, erythropoietin, and interleukin-2 Treatment strategies - 17 April 2001

• Structured treatment interruptions Conference reports - Treatment strategies - HIV 5 Glasgow 2000 - 17 December 2000

• Study shows immune system can control HIV: early antiviral treatment primes the immune system to suppress viral levels without drugs Basic science and immunology - Treatment strategies - 17 October 2000

• Human IL-12 may augment HIV-specific immunity in HIV-positive patients Treatment strategies - 17 October 2000

• Structured treatment interruptions and treatment intensification Treatment strategies - CROI 7 (Retrovirus) 2000 - 16 September 2000

• New developments in affordable antiretroviral therapy: intermittent treatment Conference reports - Treatment strategies - World AIDS 13 Durban 2000 - 16 August 2000

• Once-daily protease-based regimens Antiretrovirals - Conference reports - Treatment strategies - World AIDS 13 Durban 2000 - 16 August 2000

• What is the significance of blips in viral load? Conference reports - Treatment strategies - Intl Drug Resistance Workshop 4 Sitges 2000 - 16 July 2000

• Phase III study of GM-CSF in advanced HIV disease Treatment strategies - 15 June 2000

• GM-CSF beneficial for patients with advanced HIV disease Treatment strategies - 15 May 2000

• French National Drug Agency re-commends use of IL-2 if HAART does not lead to an increase in CD4 count to greater than 200 cells/mm3 Treatment strategies - 14 April 2000