Conference reports

Dual therapy less effective at high viral load: NEAT 001 study with raltegravir/darunavir/r

Atazanavir, raltegravir and darunavir virologically equivalent in naive patients but significant differences for tolerability: results from ACTG 5257

Pharmacokinetic targets for efavirenz might be too high

Abacavir link to cardiovascular events in high-risk patients maintained in D:A:D study

NNRTI resistance found in 12% of people stopping treatment with undetectable viral load: implications for stock-outs

HIV related infections remain the leading cause of maternal deaths in South Africa despite the availability of ART

Lower newborn bone mineral content with maternal tenofovir use

Paediatric pipeline: CROI 2014 update on new antiretrovirals for children

Efavirenz maintenance therapy effective in children exposed to nevirapine prophylaxis

Xpert TB test has important advantages but does not reduce morbidity

Reports of a second baby possibly cured of HIV: uncertainty remains

Updates on SB728-T, a CCR5-targeting gene therapy

4th International Workshop on HIV & Women, 13-14 January 2014, Washington

Women, HIV research and antiretrovirals

Improved virological outcomes for women starting efavirenz-based first-line regimens in South Africa

High rates of pregnancy in HIV positive women in Zambia and South Africa

Contraceptive choices among a Canadian cohort of HIV positive women

Bone disease and older HIV positive women

Lower immune response to the qHPV vaccine in HIV positive girls

HIV exposed vs unexposed babies have lower gestational age and birth weight in Danish study

Outcomes in infants exposed to lopinavir/ritonavir in utero

17th International Conference on AIDS and STIs in Africa (ICASA), 7-11 December 2013, Cape Town

Two percent rate of efavirenz discontinuation in an ART programme in Malawi

6th International Workshop on HIV Persistence During Therapy, 3-6 December 2013, Miami, USA

Report from the 6th Workshop on HIV Persistence

44th Union World Conference on Lung Health, 30 October – 3 November 2013, Paris

Preventing and treating TB in children – more baby steps

14th European AIDS Conference (EACS), 16-19 October 2013, Brussels

Dolutegravir superior to darunavir/r at week 48 in open label treatment naïve study

GSK744: 24-week results with oral integrase inhibitor planned for once-monthly injections

Cenicriviroc: 48 week results compared to efavirenz

Approaches to once-daily raltegravir: new formulation likely to require food

DSMB stops boosted atazanavir monotherapy study due to virological failure

Recreational drug use is common in HIV positive gay men and is extensive in a significant minority

Caution against prolonged use of bisphosphonates in patients with mild-moderate fracture risk

Osteoporosis triples risk of later fracture in 1000-person US HIV group

Bone turnover marker changes early in ART predict bone loss after 96 week

Low HDL cholesterol is main lipid abnormality in HIV+/HIV- comparison

Classic risk factors, but not HIV, linked to arterial stiffness in middle-aged

53rd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), 10-13 September 2013, Denver

Raltegravir safe and effective in pregnancy in small French study

Side effects common but mostly mild in women taking higher dose protease inhibitors in pregnancy

Good safety profile with long-acting integrase inhibitor GSK744

TAF comparable to TDF in once-daily pill for ART-naive: 48-week results

Dolutegravir superior to darunavir at 48 weeks in open-label ART-naive trial

7th IAS Conference on HIV Pathogenesis, Treatment and Prevention, 30 June – 3 July 2013, Kuala Lumpur

High prices for antiretrovirals in middle-income countries outside Africa

Comparable efficacy and pregnancy outcomes with boosted atazanavir and lopinavir at standard doses

PrEP gives little extra benefit in attempted conception if male partner is on ART

7th IAS Conference on HIV Pathogenesis, Treatment and Prevention, 30 June – 3 July 2013, Kuala Lumpur

WHO 2013 guidelines: what about the missing formulations?

WHO 2013 guidelines: when the risk:benefit may not favour starting at CD4 count of 500

Efavirenz at 400 mg compared to standard 600 mg dose has similar efficacy with fewer side effects

Dolutegravir update: drug resistance in people who are treatment-naive and -experienced

Elvitegravir/cobicisat/tenofovir/FTC: Stribild studies at IAS 2013

Non-standard combinations: NRTI-sparing combinations

ARVs and bone health: the role of NRTIs in second-line therapy

No viral load rebound off-ART following stem cell transplant: two “cure” cases using reduced intensity conditioning chemotherapy and CCR5 d-32 negative donors

HIV cure research: further capsules at IAS 2013

Partner-dependent immune differences may protect against HIV infection

Pipeline oral HCV drugs and generic global access to DAAs: the need to mirror ARV programmes

5th International Workshop on HIV Pediatrics, 28-29 June 2013, Kuala Lumpur

Vertical transmission continues to decline in UK and Ireland

Decline in late preterm delivery with vaginal birth in Europe

High loss to follow up among asymptomatic women starting ART in pregnancy in Option B+

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