Conference reports

HPTN-052: clinical advantages from earlier treatment

Hormonal contraception and the risk of HIV acquisition

Towards an HIV cure: Early developments reported at IAS, part 2

Online video interviews between researchers and activists

19th IAS World AIDS Conference, 22–25 July 2012, Washington

IAS: social and political talks online as web casts

New booster – cobicistat as an alternative to ritonavir

Dolutegravir vs raltegravir in treatment-naive patients: 48 week results from the SPRING 2 study

Elvitegravir vs raltegravir: 96 week phase III results in treatment experienced patients

In vitro and animal data support safety profile BMS 986001: d4T-like NRTI currently in clinical trials

Switching to rilpivirine/tenofovir/FTC fixed dose combination from boosted-PI regimen: SPIRIT study draws the line at 24 weeks

Maraviroc plus atazanavir/ritonavir in a nuke-sparing regimen in treatment-naive patients

Five-year results from raltegravir registrational studies

First report: atazanavir-related gallstones (cholelithiasis)

Paediatrics studies at 19th International AIDS Conference and the 4th International Workshop on HIV Pediatrics

Novel lopinavir/ritonavir sprinkle formulation for children in resource-limited settings

Update on new antiretrovirals for children and adolescents

Tenofovir prophylaxis for neonates

Efavirenz levels variable in children in the CHAPAS-3 study

Early initiation of ART is associated with growth recovery in children in NEVEREST-2

High prevalence of peripheral neuropathy in children taking d4T in rural South Africa

Lipid profile in children in PREDICT: immediate versus deferred nevirapine-based ART

High levels of maraviroc in rectal tissue fail to protect macaques from SIV transmission following rectal exposure

Mechanisms for circumcision to reduce HIV transmission in different penile tissue: target cell differences rather than keratinisation

Towards an HIV cure: early developments reported

Important publications launched at IAS 2012

14th International Workshop on Co-morbidities and Adverse Drug Reactions (IWCADR), 19–21 July 2012, Washington

Skeletal muscle toxicity and raltegravir

Proteinuria as a potential early marker of tenofovir-related renal toxicity

Earlier and greater comorbidities reported in HIV positive cohort

20th International HIV Drug Resistance Workshop, 9–13 June 2012, Sitges

In vitro resistance profile for BMS 986001

Recombination dynamics in case of MDR sub-type D following superinfection with wild-type sub-type B

Defective viral reservoir populations is common in patients on long-term suppressed ART

First case report of transmission with five-class resistance

New data on the Berlin patient: interpret with caution

18th Annual BHIVA Conference, 18-20 April 2012, UK

Half of gay men in London would chose oral PrEP to reduce risk of HIV

Recent infection is common in UK; 30% gay men aged 15-25 infected within a year of diagnosis

One third of HIV positive people at five UK clinics have symptomatic depression: link to adherence and viral suppression – 40% cases are untreated

Hodgkin’s lymphoma: survival normalises to HIV negative rates despite more advanced disease at diagnosis

Promising outcomes from laser ablative treatment of AIN2/3 to prevent anal cancer

KS in the HAART era includes patients with high CD4 and suppressed viral load: importance of KS chemotherapy for some patients in addition to ART

3rd vs 4th generation HIV testing: almost half of UK clinics out of step with national guidelines

Case reports of complications from ketamine use in two MSM on ritonavir-based combinations

Intranasal and topical corticosteroids and risk of Cushing’s symptoms in HIV patients on ritonavir-based combinations

Outcomes from switches to atazanavir/r in London

Intimate partner violence towards HIV positive women in the UK

13th International workshop on Clinical Pharmacology of HIV Therapy, 16-18 April 2012, Barcelona

Studies on pipeline ARVs

Washout pharmacokinetics of transplacental raltegravir in neonates

Interactions between malaria drugs and etravirine or darunavir/r

No interaction between antimalarial amodiaquine and nevirapine

Pharmacokinetics of atazanavir/ritonavir plus raltegravir

Atazanavir/ritonavir and voriconazole not to be coadministered

Milk thistle (silymarin) and darunavir/ritonavir

Echinacea and etravirine

Warfarin and ARVs: impact of African American race and ritonavir

19th Conference on Retroviruses and Opportunistic Infections (CROI), 5-8 March 2012, Seattle

HIV and the brain: longitudinal results from CHARTER and other studies

Systolic blood pressure and risk of myocardial infarction in HIV infection

Risk of non-AIDS defining malignancies and immune suppression

Renal impairment in the D:A:D study

Early data for rilpivirine long acting formulation supports further investigation for PrEP

Hormonal contraception: HIV transmission and progression rates

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