HTB

2012

Roche to discontinue production of nelfinavir and saquinavir 200 mg hard capsules

Volume 13 Number 7/8 July/August 2012

HIV and your quality of life: a guide to side effects and other complications (July 2012)

i-Base/TAG 2012 pipeline report

19th IAS World AIDS Conference, 22–25 July 2012, Washington

IAS: social and political talks online as web casts

New booster – cobicistat as an alternative to ritonavir

Dolutegravir vs raltegravir in treatment-naive patients: 48 week results from the SPRING 2 study

Elvitegravir vs raltegravir: 96 week phase III results in treatment experienced patients

In vitro and animal data support safety profile BMS 986001: d4T-like NRTI currently in clinical trials

Switching to rilpivirine/tenofovir/FTC fixed dose combination from boosted-PI regimen: SPIRIT study draws the line at 24 weeks

Maraviroc plus atazanavir/ritonavir in a nuke-sparing regimen in treatment-naive patients

Five-year results from raltegravir registrational studies

First report: atazanavir-related gallstones (cholelithiasis)

Paediatrics studies at 19th International AIDS Conference and the 4th International Workshop on HIV Pediatrics

Novel lopinavir/ritonavir sprinkle formulation for children in resource-limited settings

Update on new antiretrovirals for children and adolescents

Tenofovir prophylaxis for neonates

Efavirenz levels variable in children in the CHAPAS-3 study

Early initiation of ART is associated with growth recovery in children in NEVEREST-2

High prevalence of peripheral neuropathy in children taking d4T in rural South Africa

Lipid profile in children in PREDICT: immediate versus deferred nevirapine-based ART

High levels of maraviroc in rectal tissue fail to protect macaques from SIV transmission following rectal exposure

Mechanisms for circumcision to reduce HIV transmission in different penile tissue: target cell differences rather than keratinisation

Towards an HIV cure: early developments reported

Important publications launched at IAS 2012

14th International Workshop on Co-morbidities and Adverse Drug Reactions (IWCADR), 19–21 July 2012, Washington

Skeletal muscle toxicity and raltegravir

Proteinuria as a potential early marker of tenofovir-related renal toxicity

Earlier and greater comorbidities reported in HIV positive cohort

20th International HIV Drug Resistance Workshop, 9–13 June 2012, Sitges

In vitro resistance profile for BMS 986001

Recombination dynamics in case of MDR sub-type D following superinfection with wild-type sub-type B

Defective viral reservoir populations is common in patients on long-term suppressed ART

First case report of transmission with five-class resistance

New data on the Berlin patient: interpret with caution

Dolutegravir indicates superiority compared to efavirenz in treatment-naïve patients: top-line results only

FDA update to darunavir label: severe skin reactions

FDA approval of generic ARVs

Activists protest at IAS for Global Fund to stick to principles

EU parliament rejects anti-counterfeiting trade agreement: allows continued access to generic medicines

US trade deal threatens access to medicines

Theratechnologies withdraw EU application for tesamorelin (Egrifta)

FDA approve Truvada to reduce the risk of sexual transmission

Recent studies on HIV, ART and osteoporotic fracture risk

Role of cell-to-cell transmission in sustaining the HIV reservoir

ACT-UP in film: ‘How to survive a plague’ and ‘United in anger’

PLoS Medicine (July 2012)

AIDS 2012: non-technical conference summaries: HTB supplement

Volume 13 Number 7/8 July/August 2012 PDF

2012 pipeline report launched in Washington: HIV, HCV, TB, PEP, cure and vaccine research

Press release: 2012 pipeline report launched in Washington

HTB supplement: 2012 pipeline report

Introduction and executive summary

The antiretroviral pipeline 2012

The pediatric antiretroviral pipeline

Retrofitting for purpose: treatment optimisation 2012

Preventive technologies, research toward a cure, and immune-based and gene therapies

Hepatitis C drug development goes from pony ride to rocket launch

Hepatitis C (HCV) treatment access: spotlight on Thailand/Asia

The tuberculosis diagnostics pipeline

The tuberculosis treatment pipeline

The tuberculosis vaccine pipeline

Acknowledgments

Volume 13 Number 5/6 May/June 2012

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