Coinfections and complications

opportunistic infections, coinfections and complications

Detectable viral load quadruples odds of recurrent falls in older men with HIV

More than 40% of HIV group has hepatic steatosis, regardless of age

Associations of loneliness with cognitive function and quality of life (QoL) among older adults living with HIV – 18% lonely quite often

Physical function worse in older women than men with HIV, despite better CD4 recovery

Changing comorbidities in HIV positive people older than 60 at London clinic

High acceptability of annual digital (finger) exam for early detection of anal cancer in gay men >35 years old

RITA: issue on lung health

US study tracks kidney transplant results from HIV positive donors

Not claptrap: kissing as the strongest route for oral gonorrhoea

No increased risk of IRIS in people with low CD4 counts receiving raltegravir in the REALITY trial

Reducing risk of myocardial infarction (MI) in HIV positive people

Reducing rates of HIV-related cancer in US from 1996-2012

Effects of the anti-inflammatory antibody canakinumab on heart disease and cancer: implications for HIV?

Enhanced OI prophylaxis reduces mortality when starting ART late

Increased frequency and progression of kidney disease in HIV positive people

Impressive HIV pipeline at CROI 2017

Paediatric HIV: CROI 2017

Increased prevalence of diabetes in HIV positive people

Poppers and cancer risk in HIV negative and HIV positive gay men

Other selections and webcasts

Increased risk of IRIS with integrase inhibitors reported in two studies

Breakthrough for treating XDR-TB and ameliorating TB-IRIS

Effects of ART initiation on human papillomavirus antibody response

Rosuvastatin for chronic obstructive pulmonary disease (COPD) in people with HIV

AT LAST: Gay men and transgender people in England get vaccine to prevent genital warts and anal cancer – impressive pilot results

Higher rates of eye complications in HIV positive people on ART

High prevalence of multiple high-risk HPV infections in young HIV positive gay men

Non alcohol fatty acid liver disease: an emerging problem

HIV positive people on ART have impaired alveolar immunity

START substudies: increased quality of life from earlier treatment but no impact on vascular function or cardiovascular markers

Impact of early ART on lung function: results on ART and COPD from START substudy

No difference in neuropsychological test results between early and delayed ART in START substudy

HIV and cardiovascular disease

Increased cardiovascular risks in HIV positive children in Uganda and Zambia partially reversed by ART

Recommendations for management of bone disease in HIV

FDA approves 9-valent HPV vaccine: active against types 6, 11, 16, 18, 31, 33, 45, 52 and 58

CMV associated with 50% increased risk of non-AIDS related mortality in HIV positive people

Impact of smoking on life expectancy in HIV infection

High prevalence of COPD at baseline in START study sub-study

Immunotherapy for PML: two case reports using IL-7 and experimental recombinant JCV VP1 protein therapeutic vaccination

Kidney signal trouble worsens over 5 years in Japanese on tenofovir

Caution against prolonged use of bisphosphonates in patients with mild-moderate fracture risk

Osteoporosis triples risk of later fracture in 1000-person US HIV group

Bone turnover marker changes early in ART predict bone loss after 96 week

Classic risk factors, but not HIV, linked to arterial stiffness in middle-aged

Cardiovascular disease and other non-AIDS defining events

RIFAQUIN study demonstrates once-weekly dosing during follow-up phase of TB treatment

Combining Xpert and LAM urine testing improves TB diagnostic sensitivity

Deferring ART by four weeks reduces mortality in patients diagnosed with cryptococcal meningitis

One third of HIV positive people at five UK clinics have symptomatic depression: link to adherence and viral suppression – 40% cases are untreated

Hodgkin’s lymphoma: survival normalises to HIV negative rates despite more advanced disease at diagnosis

Promising outcomes from laser ablative treatment of AIN2/3 to prevent anal cancer

KS in the HAART era includes patients with high CD4 and suppressed viral load: importance of KS chemotherapy for some patients in addition to ART

HIV and the brain: longitudinal results from CHARTER and other studies

Systolic blood pressure and risk of myocardial infarction in HIV infection

Risk of non-AIDS defining malignancies and immune suppression

Renal impairment in the D:A:D study

No association between atazanavir and MI or stroke in D:A:D study

No increased risk of non-AIDS deaths from cumulative use of ART in EuroSIDA cohort

HIV linked to frailty in middle-aged IDUs, especially with poor HIV control

US guidelines for management of older people living with HIV (2011)

New studies on HIV and the diseases of ageing

Risk of cataract surgery higher in HIV positive compared to HIV negative people

CD4 count <200 independently associated with 5-fold increased risk of fracture

Hearing loss not associated with HIV in MACS and WIHS cohorts

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