HTB

2021

Dolutegravir superior to standard of care in children and adolescents: results from the ODYSSEY trial

High efficacy of HPV vaccine in HIV positive gay men

HPV vaccine does not prevent short-term recurrence of high grade lesions in HIV positive gay men

HIV bNAbs prevent intravenous exposure to SHIV in macaques as PrEP

HIV associated with higher risk of severe COVID-19 in US cohort

MHRA authorises Janssen/J&J COVID-19 vaccination in the UK

Reduced antibody responses to first dose of mRNA COVID-19 vaccines in HIV positive people with a lower CD4 count

France routinely recommends third dose of COVID-19 vaccine for some people with reduced immune function

US CDC reports 10,000 breakthrough infections after full vaccination: showing success of vaccine programme

Cases of COVID-19 reported including deaths in care home residents after full-course vaccination

Israeli study reports reduced vaccine efficacy in people with immune suppression until 14 days after the second dose

Novavax reports 43% efficacy against B.1.351 South African variant but negative impact in HIV positive participants

Oxford/AZ vaccine linked to 242 rare bloods clots in the UK: alternative recommended for people younger than 40

COVID-19 vaccine candidate from GSK and Sanofi to move to phase 3 placebo controlled study

Meta-analysis of 18 ivermectin studies

Asymptomatic infection has similar SARS-CoV-2 viral load to mild COVID-19

Missed TB diagnoses during COVID-19 outbreaks despite prolonged respiratory symptoms

Correlation between COVID-19 severity and immune responses after six months

Durable antibody responses 9 months after exposure irrespective of symptoms: broader vaccine coverage still needed to reach herd immunity

HTB: no. 6 – plus HIV and COVID-19 (1 June 2021)

HTB: no. 5 – plus HIV and COVID-19 (3 May 2021)

In memory: Paul Decle – community activist, gardener and friend

Joint BHIVA/BASHH Spring Conference 2021

BHIVA registry reports HIV is independently linked to worse presentation and outcomes from COVID-19

HIV is linked to higher mortality from COVID-19 compared to HIV negative: 60% of deaths were black ethnicity

Case-control study of HIV positive people hospitalised with COVID-19

UK government to cut international HIV support to UNAIDS by 80%

NICE guidelines on management of chronic pain: exercise but not opiods

US CDC includes HIV as medical criteria for priority to COVID-19 vaccines

Review of research into SARS-CoV-2 and HIV coinfection

Similar immune responses to the Oxford/AZ COVID vaccine reported In HIV positive people with high CD4 counts

Low responses to mRNA COVID-19 vaccines in those older than 80 vs <60 years and in recipients of solid organ transplants

Two cases of viral breakthrough infections despite full protection from Pfizer mRNA vaccination

US post-authorisation safety data on Pfizer and Moderna vaccines

EMA review of Oxford/AZ vaccine and rare blood clots reported in the EU

Interim results report 80% efficacy for India’s COVAXIN vaccine

Three new COVID-19 vaccine studies enrolling in the UK

Dexamethasone: final results from RECOVERY study

No impact from anakinra in mild/moderate COVID-19 pneumonia

Bar opening in the US: 100 guests linked to at least 46 cases of COVID-19

Long COVID: studies reporting on long-term follow up on COVID-19

Large sporting event in US linked to 649 cases of COVID-19

Three carefully documented cases of SARS-CoV-2 transmission in a hospital setting despite masks

HTB: no.5 – plus HIV and COVID-19 (3 May 2021)

HTB: no. 4 – plus HIV and COVID-19 (1 April 2021)

28th Conference on Retroviruses on Opportunistic Infections (CROI 2021)

CROI 2021: First results using capsid inhibitor lenacapavir against MDR HIV: potential for six-monthly ART and PrEP

CROI 2021: Pregnancy outcomes and weight gain with dolutegravir and TAF

CROI 2021: New compounds for prevention and treatment of COVID-19

Oral molnupiravir at higher dose reduces SARS-CoV-2 viral load at day five in small phase 2 study

Bamlanivimab prophylaxis reduces hospitalisation and mortality: results from phase 3 BLAZE-2 study

Dual Eli-Lilly mAb bamlanivimab and etesevimab reduces hospitalisation after single infusion: results from BLAZE-1 study

Dual Regeneron mAbs casirivimab with imdevimab reduce transmission: interim results from phase 3 study

CROI 2021: Presentations from the LEAP workshop 2021

CROI 2021: Presentations on NATAP.org

Gilead and Merck/MSD to collaborate on long-acting HIV combination of lenacapavir and islatravir

Calls to reverse proposed UK cuts to global health research

BHIVA guidelines on COVID-19 vaccines and people living with HIV: DRAFT online for comment

BHIVA advice on access to COVID-19 vaccines and shielding in the UK

US phase 3 results enable FDA review of the Oxford/AstraZeneca vaccine

HTB: no.4 – plus HIV and COVID-19 (1 April 2021)

Switch study for people with insomnia using dolutegravir

HTB: no. 3 – plus HIV and COVID-19 (12 March 2021)

In memory: Dr Charles Boucher – leading HIV doctor, researcher and educator

28th Conference on Retroviruses and Opportunistic Infections (CROI 2021)

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